【中图分类号】R285.5 【文献标志码】A 【文章编号】1007-8517（2025）12-0030-05

DOI： 10.3969/j . issn.1007-8517.2025.12. zgmzmjyzz202512008

Abstract：ObjectiveThisstudyaims toinvestigate theanti-inflammatoryefectofTongfengLianCapsuleonacutegoutyarthritis anditsunderlying mechanisms.MethodsArandomizedcontroleddesignwasadopted，andSPF-graderatsweredividedintofour groups：model group，colchicine group，Tongfeng LianCapsulegroup，andnormalcontrolgroup.Theacutegoutyarthritis odelwas inducedby monosodiumurate（MSU）crystals，andthecoespondingdrugsornormalsalinewereadministered.Jointswellngindex was measured at 1h before modeling and at 2 h， ^4h ！ 6h ，and 12h after modeling.After 3 days，samples were collected to detect the levels of IL-1β ， TNF-α ，PGE2，TGF-β1，and 1L-8 in serum，as well as the expression levels of NALP3，TLR4，and NF- κB （20 p65 proteins andmiRNA-146αmRNA insynovial tssue.ResultsCompared with thenormalcontrolgroup，ratsinthemodel group showedsignificant inflammatoryresponses，with significantlyincreasedankle jointswellngrate，serum inflammatoryfactors （IL-1β TNF-α ，PGE2，TGF-β1，IL -8），and expression levels of NALP3，TLR4，and NF - κκκ p65 proteins in synovial tissue. The level of miRNA -146α in synovial tissue wassignificantly decreased.Compared with the model group，theankle joint swellingrate，serum inflammatory factors（ IL-1β ， TNF-α ，PGE2，TGF-β1，IL-8），and expresson levels of NALP3 and TLR4 proteins in synovial tissue were significantly reduced in the Tongfeng Lian Capsule group，while miRNA -146α in synovial tissue was significantly upregulated.There was no significant difference in NF- κB p65 protein expression. Conclusion Tongfeng Lian Capsule exhibits a significant anti-inflammatoryefectonAGAanditsmechanismmayinvolveinibitinginfammatoryresponsesthroughtheregulationofmiNA -146α and the TLR4/NALP3 signaling pathway.This providesa scientific basis fortheclinical aplicationof Tongfeng LianCapsule.

Key Words：Tongfeng Lian Capsule;Gouty Arthritis；Inflammatory

痛风性关节炎（goutyarthritis，GA，简称痛风）是一种常见的关节炎症，其发病常伴随不良的饮食习惯和生活方式1]，具有高发性、致残性和反复性等特点。急性痛风性关节炎（acutegoutyarthritis，AGA）发作时的疼痛非常剧烈，同时伴有关节僵硬、活动受限等症状，会直接影响患者的肢体功能[2]。炎性浸润是急性痛风性关节炎重要病理改变， miR-146α 在TLR4和NALP3炎性体信号通路发挥关键调控作用，并与急性痛风性关节炎发生关系密切。研究[3]发现 miR-146α 可能间接靶向NALP3炎症小体以改善 IL-1β 的活化，减少痛风的炎性反应。因此研究通过 miR-146α 及TLR4/NALP3炎性体信号通路，降低炎症水平，减少患者疼痛是痛风治疗药物最紧迫的要求。

目前临床常用的治疗痛风的抗炎药物有秋水仙碱、非甾体抗炎药和糖皮质激素[4]。虽然这些药物可以缓解局部疼痛症状，但是长期使用会产生很多不良反应，轻则产生胃肠道反应，严重则会导致肾功能衰竭[5]。根据痛风的临床表现，其可归属于中医“历节”“痹证”的范畴，中医药治疗具有较好且安全的治疗效果，其在降尿酸、抗炎和改善关节功能方面经现代研究发现更具有优势[6]

痛风立安胶囊是广西国际壮医医院风湿病科李凤珍主任医师临床总结的壮药经验方，由肿节风、虎杖、忍冬藤、粉草、车前草、徐长卿、透骨草、甘草组成，通龙路火路之气机，具有清热毒、除湿毒、祛风毒、消肿痛等功效。多年临床应用发现，其对痛风急性发作期的关节疼痛、肿胀及活动受限等症均有明显改善[7]，但其具体作用机制尚未明晰。……