EffectofRepetitive TranscranialMagnetic StimulationCombinedwithSertralineonPsychological State and Cognitive Function of Adolescent Patients with Depression/CHENSiyi，GU Junying，KUANG Yanmei.//Medical InnovationofChina，2025，22（20）：137-140

[Abstract] Objective：To investigate the effect of repetitive transcranial magnetic stimulation combined with Sertralineonadolescent patientswithdepression.Method：Atotalof 1OOadolescent patientswithdepression who admitted to thePediatricandAdolescent Health，Shangrao Third People'sHospital from November 2023 to November 2O24 were selected，and they were divided into the observation group （ n= ：50，repetitive transcranial magnetic stimulation combined with Sertraline treatment） and the control group （ n =50，Sertraline treatment） by the random number table method，both groups were treated continuously for 2 weeks.The psychological state，cognitive function，impulsive behavior，qualityof lifeand clinical efect were compared between two groups.Result：After treatment，the HAMD score in the observation group was （ 10.02±1.17 ） points，the HAMA score was （9.69 ± 1.21） points，which were lower than （15.79±1.28） and （14.81±1.35 ）pointsin the control group，the MoCA score in the observation group was（ 22.85±1.02 ）points，the mini mental state examination （MMSE） score was （22.24±2.22 ） points，which were higher than （ 18.77±1.15 ） and （19.17±1.28 ）points of the control group，the impulsive behavior score of the observation group was （ 15.25±2.14 ）points，whichwaslower than （20.54±3.51 ）points of the control group，the quality of life score of the observation group was （89.25±3.25 ）points，which was higher than （80.14±3.04） points of the control group，the differences were statistically significant （ P lt;0.05）;the total effective rate of the observation group was higher than that of the control group，the difference was statistically significant （ P lt;0.05）.

Conclusion： Thecombination of repetitive transcranial magnetic stimulationand Sertraline can efectively enhance psychological state，cognitivefunctionand impulsivebehaviorof adolescent patients withdepression，improve quality of life and clinical effects.

[Keywords] Depression Adolescent Repetitive transcranial magnetic stimulation Sertraline 'sychological stateCognitive function

First-author'saddress： PediatricandAdolescentHealth，Shangrao ThirdPeople'sHospital，Shangrao 334000， China

doi： 10.3969/j.issn.1674-4985.2025.20.032

青少年抑郁症主要症状为情绪低落、思维迟缓、活动减少及言语不多，同时伴随不同程度认知功能受损，是精神科中常见的一种疾病[。此病对患者的日常生活、学习及社交活动均会产生诸多不良影响，且在严重情况下，患者可能表现出暴力倾向或自杀等危险行为[2。目前，临床治疗青少年抑郁症主要采取药物治疗，其中舍曲林因确切提升5-羟色胺（5-HT）水平及兴奋神经，常用于治疗抑郁症。但单一用药疗效有限，还需探究更有效的治疗方案3。重复经颅磁刺激利用脉冲刺激大脑特定部位，影响大脑局部生物电，促进脑组织局部位置新陈代谢，从而减轻患者症状[4。基于此，本研究分析重复经颅磁刺激联合舍曲林对青少年抑郁症患者的影响，现报道如下。

1资料与方法

1.1一般资料

选择2023年11月—2024年11月上饶市第三人民医院收治的100例青少年抑郁症患者。（1）纳入标准：符合文献[5]《儿童及青少年抑郁的诊断和管理：NICE指南更新概要》中相关诊断标准；年龄13＼～18岁；无其他严重躯体疾病；依从性良好。（2）排除标准：患有其他精神类疾病或精神发育迟滞；伴有小儿痴呆、癫痫等严重疾病；存有严重自杀倾向；药物依赖；视听障碍或语言表达障碍；因个人原因中途退出。患者家属均了解本研究情况，并均已签署知情同意书。本研究获上饶市第三人民医院医学伦理委员会批准（2023审11号）。

1.2 方法

对照组予以舍曲林（海南凯健制药有限公司，国药准字H20070292， 50mg ）治疗。起始剂量25mg/d ，根据患者情况及耐受度调整剂量，2周内增至 150mg/d 。……