Effect of Calcium Gluconate Combined with Carboprost Tromethamine on Postpartum Hemorrhage of TwinCesarean Section/LYUMengqin，HUANGLimin，WANHeping.//Medical InnovationofChina， 2025，22（20）：133-136

[Abstract]Objective：To explore the preventive effect of Calcium Gluconate combined with Carboprost Tromethamine on postpartum hemorrhageof twin cesarean section.Method： Aretrospective analysis was conducted on the clinical data of1OO parturients who underwent twin cesarean section delivery in the First People's Hospital of Fuzhou City from January 2O22 to August 2O24.They were divided into the control group and the observation group according to differenttreatment methods，with 5O cases ineach group.The control group received conventional preventive and treatment measures for postpartum hemorrhage，and the observation group was treated with Calcium Gluconate combined with Carboprost Tromethamine on the basis of conventional treatment.The blood loss 24 hours afterdelivery，bloodroutine and coagulation function indicatorslevels were comparedbetweenthetwo groups，and the postpartum hemorhageand surgical hemostasis were recorded.Result：The blood loss24 hours afterdelivery in the observation group was less than that in the control group，and the RBC，hematocrit and Hb 24 hours after" delivery were significantly higher than those in the control group，the PTand APTT were significantly shorter than those in the control group （ Plt;0.05 .There were no statistically significant diferences between the two groups in the rates of postpartum hemorrhage，hysterectomy and uterine artery embolization between the two groups （ Pgt;0.05） Conclusion： Calcium Gluconate combined with Carboprost Tromethamine has a better application effect in twin cesarean section parturientsand is helpful to reduce the blood loss 24 hours after delivery.

[Keywords] Twin pregnancy Cesarean section Postpartum hemorrhage Calcium Gluconate Carboprost [romethamine

First-author's address：Department of Gynaecology and Obstetrics，the First People's Hospital of Izhou City，Fuzhou344000，China doi：10.3969/j.issn.1674-4985.2025.20.031

双胎妊娠因其独特的生理特点，往往伴随更高的妊娠和分娩风险，其中产后出血是双胎剖宫产常见且严重的并发症之一l。产后出血不仅导致贫血、感染等并发症，威胁产妇生命安全，还会对产妇的心理健康造成不良影响[。因此，如何有效控制双胎剖宫产术中出血量、降低产后出血发生率，是当前临床产科研究的重要课题。近年来，随着药物和手术技术的进步，多种方法被应用于控制剖宫产产后出血。卡前列素氨丁三醇因其强效的宫缩作用，被广泛用于产后出血的防治，然而，单一使用宫缩药物效果有限，部分产妇仍会出现较多出血，影响恢复效果[3-4]。葡萄糖酸钙作为一种常见的补钙药物，近年研究表明其具有一定的止血效果[5-，通过促进血小板聚集在止血方面表现出积极作用[。因此，将葡萄糖酸钙与卡前列素氨丁三醇联合使用，可能在控制双胎剖宫产产后出血中发挥协同作用。本研究旨在评估葡萄糖酸钙联合卡前列素氨丁三醇应用于双胎剖宫产产后出血的临床效果，希望为双胎剖宫产产后出血的防治提供一种更为安全、有效的干预手段，进一步完善产科出血管理措施，改善产妇预后，提高分娩质量。

1资料与方法

1.1一般资料

回顾性分析2022年1月—2024年8月在抚州市第一人民医院行剖宫产的双胎产妇100例的临床资料。纳入标准：（1）双胎妊娠并行剖宫产术；（2）术前无严重凝血功能障碍；（3）接受葡萄糖酸钙和卡前列素氨丁三醇的常规使用；……