Effect of Probiotics Combined with Quadruple Therapy in the Treatment of Helicobacter Pylori Positive Gastric Ulcer and Its Influence on the Gastric Mucosal Function of Patients/YANG Qun， CHEN Lifang，TUYuhua，WUJinjiao.//MedicalInnovationofChina，2025，22（19）： 006-009

[Abstract]Objective： To investigate the efectof probioticscombined with quadruple therapyinthe treatment of patientswith Helicobacter pylori （ H_P ）positive gastric ulcer.Method：A total of 1O3 patientswith Hp positive gastric ulcer admited tothe Maternityand Child Health Hospitalof Jianand Ji'anCentral People'sHospital from January 2O2O to December 2O21 were included as theresearch subjects and divided into groupA （n=51）and group B 0 n =52） by the random number table method.The group A was treated with quadruple therapy，and the group B was treated with Bifidobacterium Triple Viable Capsules on the basis of group A.Both groups were treated for 14 days， and thenacid suppressants were continued to be taken for2 weeks.The therapeutic effct， gastric mucosal function， inflammation-related indicatorsandadversereactions ofthe two groups were compared.Result：The total effective rate of group B was higher than that of group A（ P lt;0.05）.Compared withbefore treatment，after treatment， the levels of pepsinogen II（PGII），serumamyloid A （SAA）， IL-17and procalcitonin （PCT） inboth groups decreased，the levels ofPGI，SAAandIL-17 in group B werelower than those ingroup A，the pepsinogen I （PGI），somatostatin （SS）levels in both groups increased，and those in group B were higher than those in group A（ P lt;0.05）. There was no statisticallysignificant difference in the total incidence of adverse reactions between the two groups （ P gt;0.05）.

Conclusion：Probiotics combined with quadruple therapy is efective in the treatment of Hp positive gastric ulcer， which can improve gastric mucosal function and inflammation-related indicators，and has good safety.

[Key words]Helicobacter pylori Gastric ulcerProbioticsQuadruple therapy

First-author'saddres： Department of Endoscopy，the Maternity and Child Health Hospital of Ji'an， Ji'an 343000， China doi：10.3969/j.issn.1674-4985.2025.19.002

幽门螺杆菌（ Hp ）阳性胃溃疡主要症状包括胃痛、胃胀等[。四联疗法通过质子泵抑制剂抑制胃酸分泌、铋剂保护胃黏膜，另借助两种抗生素杀灭Hp，但随着抗生素的广泛使用， Hp 的耐药率逐渐上升[。益生菌可调节肠道菌群，增强机体免疫力，与四联疗法协同作用，可进一步提高 Hp 清除率。双歧杆菌三联活菌胶囊是一种微生态制剂，在调节肠道菌群平衡、改善肠道功能、增强免疫等方面有一定优势[3。但二者联合对 Hp 阳性胃溃疡患者胃黏膜功能的影响仍需更多临床数据支持。基于此，本研究旨在探讨益生菌联合四联疗法治疗 Hp 阳性胃溃疡的效果及对患者胃黏膜功能的影响，现报道如下。

1资料与方法

1.1一般资料

纳入吉安市妇幼保健院和吉安市中心人民医院2020年1月—2021年12月收治的103例 Hp 阳性胃溃疡患者作为研究对象。纳入标准：符合胃溃疡诊断标准[4]； ¹³C 呼气试验为阳性；就诊前1个月未服用胃溃疡治疗相关药物；单发病灶。排除标准：复发性、恶性溃疡；有胃切除术史；合并肝、肾功能不全；凝血功能异常；过敏体质。以随机数字表法将患者分为A组（ n=51 ）B组（ n=52 ）。此研究经吉安市妇幼保健院和吉安市中心人民医院医学伦理委员会批准，患者或家属对本研究知情同意。

1.2 方法

A组采用四联疗法：雷贝拉唑钠肠溶片（上海上药信谊药厂有限公司，国药准字H20031292， 10mg ）10mg/ 次，餐前 30min 口服；胶体果胶铋胶囊（山西邦仕得药业有限公司，国药准字H20063860， 100mg ）200mg/ 次，餐前 30min 口服；克拉霉素片（浙江贝得药业有限公司，国药准字H20083281， 0.25g ）0.5g/ 次，餐后口服；……