Effect of External Application of Mangxiao Combined with Ulinastatin in the Treatment of Acute Pancreatitisand Its Influenceon Laboratory Indicators Levels/FUMingen，YI Suhong.//Medical Innovation of China，2025，22（18）：131-134

[Abstract]Objective：To explore the efect of external application of Mangxiao combined with Ulinastatin in thetreatmentofacute pancreatitis （AP）and its influenceonlaboratory indicators levels.Method：A total of 82 patients with APadmited to XinyuPeople's Hospital from June2O23 to June 2024 were selected and grouped bythe random number table method，with 41cases in the experimental groupand41 cases inthe control group.Thecontrol group was treated with Ulinastatin.Based on this，the experimental group was treated with external application of Mangxiao.The therapeutic efect，symptoms disappearance time，laboratory indicators，intestinal mucosal barrier functionand adverse reactions of the two groups were compared.Result： Compared with the control group，the total effectiverateof theexperimental groupwashigher，andthedisappearance timeofabdominal pain，nausea and vomiting and abdominal bloating were earlier （ P lt;0.05）.After treatment，compared with the control group，the levels of amylase （AMY）， white blood cellcount （WBC）， C reactive protein （CRP），endotoxin （ET），diamine oxidase （DAO） and D-lactic acid in the experimental group were lower，the diferences were statistically significant （ P lt;0.05）. No serious adverse reactions occurred in both group during the treatment period.Conclusion： External appication of Mangxiao combined with Ulinastatincan improve the laboratory indicators and intestinal mucosal barier functionof patients withAP，accelerate the relief ofsymptoms and improve the therapeutic effect，and itis safe.

[Key words]Acute pancreatitisExternal applicationof MangxiaoUlinastatinIntestinal mucosal barrier function

First-author's address： Department of Gastroenterology， Xinyu People's Hospital， Xinyu 338000， China

doi：10.3969/j.issn.1674-4985.2025.18.030

急性胰腺炎（AP）常见临床表现有发热、上腹疼痛、血尿淀粉酶升高等，相关研究认为，其主要因胰酶激活异常而致，通常伴有全身炎症反应和肠黏膜屏障功能受损表现，炎症细胞在分泌过量氧自由基后，会进一步加剧AP炎性损伤，致其他脏器功能障碍[1-2]。乌司他丁为临床治疗AP常用药，可抑制脂肪酶、胰蛋白酶活性减轻胰腺自身消化作用，且能拮抗白细胞异常激活，减轻炎症反应，一定程度保护胰腺细胞，但单独使用疗效有限[3-4]。近年，中医、西医相结合的治疗方案在急腹症中的作用逐渐凸显。芒硝外敷为AP常见辅助治疗手段之一，基于“内病外治”理念，对减少胰周渗液、促进炎症因子吸收有明显效果[5。但临床上关于芒硝外敷、乌司他丁联合应用于AP的报道较少，鉴于此，本研究将分析该方案对AP的效果及对实验室指标水平的影响，具体信息如下。

1资料与方法

1.1一般资料

选择新余市人民医院2023年6月一2024年6月收治的AP患者82例。纳入标准：满足AP诊断；年龄 gt;18 岁；依从性较好，且能正常沟通。排除标准：伴胃肠穿孔、肠梗阻等其他急腹症；对试验所用药物不耐受；精神疾病；有明确手术指征；坏死性AP、慢性胰腺炎急性发作、爆发性胰腺炎；伴血液系统、呼吸系统、自身免疫系统疾病。患者以随机数字表法分组，试验组、对照组各41例。本研究经新余市人民医院医学伦理委员会批准。患者自愿参与试验，签订知情同意书。

1.2 方法

两组均予营养支持、抑制胰酶活性、纠正水电解质紊乱、抗感染、禁食及胃肠减压等常规治疗。……