Effectsof Naoan Capsules Combined with Butylphthalideon Neurological Functionand Cognitive Function inPatientswithCerebral Infarction/LI Sirou，PINGTianxiao，LIAO Weiwei.//Medical Innovation of China，2025，22（18）：024-027

[Abstract] Objective：To investigate the effects of Naoan Capsules combined with Butylphthalide on neurological functionand cognitive functioninpatientswithcerebral infarction.Method：Atotalof12O patients with cerebral infarction who were admited to Central Hospital of Xinyu Ironand SteelGroupCo.，LTD.from March 2023 to March 2O24 were selectedand grouped by the random number table method，with 6O cases in the control group and 6O cases in the experimental group.The control group was given intravenous infusion of Butylphthalide， based on the control group，the experimental group was given Naoan Capsules.The therapeutic efect， neurological function，cognitive function，oxidative stress indicators and adverse reactions of the two groups were compared. Result： The total effective rate of the experimental group was 95.00% ，whichwas significantly higher than 83.33% （20 of thecontrol group，the differencewas statistically significant（ P lt;0.05）.After treatment， the scores of national institutes of health stroke scale （NIHSS） decreased and mini-mental state examination （MMSE） increased in both groups，and the NIHSS score of the experimental group was lower than that of the control group，the MMSE score was higher than that of the control group，the differences were statistically significant （ P lt;0.05）.After treatment， superoxide dismutase （SOD）and glutathione peroxidase （GSH-Px） increased and malondialdehyde （MDA） decreased in both groups，and SOD and GSH- ⋅Px in the experimental group were higher than those in the control group，MDA waslower than that in the control group，the differences were statistically significant （ P lt;0.05）.No obviousadverse reactions occured in both groups.Conclusion： Naoan Capsules combined with Butylphthalide is effctive in the treatmentofcerebral infarction，whichcanalleviatetheoxidativestress injuryofpatients，improve neurologicaland cognitive function，and has high safety.

脑梗死为常见神经血管性疾病，常由脑部血液循环异常所致，不但可导致脑疝、脑水肿、感染等诸多并发症，还可导致语言障碍、失明、瘫痪等严重后遗症，增加其死亡风险[。目前该病治疗主要注重恢复血流及保护神经细胞，以降低继发性神经损伤，改善患者预后。丁苯酞为治疗脑梗死常用药，通过调节细胞内钙浓度、抗氧化和抗炎、改善脑能量代谢、改善侧支循环等遏制脑梗死病理过程，发挥强效抗脑缺血作用，但单药治疗效果有限[2-3]。脑安胶囊有益气活血、通络化瘀之功，药理研究表明其有扩张脑血管、抗血小板聚集、增加脑血流量等作用，对改善脑梗死患者预后有积极作用[4。鉴于此，本研究分析脑安胶囊联合丁苯酞对脑梗死患者神经功能及认知功能的影响，具体信息如下。

1资料与方法

1.1一般资料

选择2023年3月—2024年3月新余钢铁集团有限公司中心医院接诊的120例脑梗死患者。纳入标准：满足脑梗死诊断5；首次发病，发病至入院时间 ⩽4.5h ；发病前无认知、精神障碍。排除标准：对试验所用药物不耐受；伴吞咽障碍；伴内分泌、血液系统等严重原发疾病；伴恶性肿瘤；伴颅内感染或颅脑外伤。患者以随机数字表法分组，对照组、试验组各60例。本研究经新余钢铁集团有限公司中心医院医学伦理委员会批准。患者或监护人知情，签订同意书。

1.2方法

两组均予相同综合处理，包括控制血糖和血压、监测生命体征、营养支持、抗血小板聚集、改善脑循环、预防并发症、早期康复训练等。……