喻晨 刘庆丰

【摘要】 目的：探究血常規衍生炎症指标及协同刺激分子B7家族在系统性红斑狼疮患者中的表达。方法：选取2019年6月—2022年10月当阳市人民医院收治的164例系统性红斑狼疮患者及在本院体检的健康志愿者41例。系统性红斑狼疮疾病活动度指数（SLEDAI）评分≥15分患者为A组（n=41），SLEDAI评分10～14分患者为B组（n=41），SLEDAI评分5～9分患者为C组（n=41），SLEDAI评分0～4分患者为D组（n=41），体检健康者为E组（n=41）。比较五组的血常规衍生炎症指标[中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、中性粒细胞和单核细胞之和/淋巴细胞比值（NMLR）及衍生的中性粒细胞/淋巴细胞比值（dNLR）]及协同刺激分子B7家族，采用Pearson相关性分析血常规衍生炎症指标与协同刺激分子B7家族的关系。结果：A组、B组、C组及D组的血常规衍生炎症指标均显著高于E组，A组、B组及C组均显著高于D组，A组及B组均显著高于C组，A组均显著高于B组，差异均有统计学意义（P<0.05）；A组、B组、C组及D组的协同刺激分子B7家族均显著低于E组，A组、B组及C组均显著均低于D组，A组及B组均显著低于C组，A组均显著低于B组，差异均有统计学意义（P<0.05）；Pearson相关性分析显示，系统性红斑狼疮患者NLR、PLR、NMLR、dNLR与协同刺激分子B7家族3（B7-H3）、协同刺激分子B7家族4（B7-H4）均呈负相关（P<0.05）。结论：血常规衍生炎症指标及协同刺激分子B7家族在系统性红斑狼疮患者中的表达显著异常，且上述指标之间有密切的关系。

【关键词】 血常规衍生炎症指标 协同刺激分子B7家族 系统性红斑狼疮 疾病活动度

Changes of Blood Routine Derived Inflammatory Indexes and Costimulation Molecule B7 Family in Patients with Systemic Lupus Erythematosus/YU Chen， LIU Qingfeng. //Medical Innovation of China， 2024， 21（08）： -146

[Abstract] Objective： To investigate the expression of blood routine derived inflammatory indexes and costimulation molecule B7 family in patients with systemic lupus erythematosus. Method： A total of 164 patients with systemic lupus erythematosus and 41 healthy volunteers who underwent physical examination in Dangyang People's Hospital from June 2019 to October 2022 were selected. Patients with systemic lupus erythematosus disease activity index （SLEDAI） score ≥15 scores were group A （n=41）， patients with SLEDAI score 10-14 scores were group B （n=41）， patients with SLEDAI score 5-9 scores were group C （n=41）， patients with SLEDAI score 0-4 scores were group D （n=41） and the healthy person in physical examination were in group E （n=41）. Blood routine derived inflammatory indexes [neutrophil/lymphocyte ratio （NLR）， platelet/lymphocyte ratio （PLR）， the sum of neutrophil and monocyte/lymphocyte ratio （NMLR） and derived neutrophil/lymphocyte ratio （dNLR）] and the costimulation molecule B7 family were compared among the five groups. Pearson correlation was used to analyze the relationship between blood routine derived inflammatory indexes and costimulation molecule b7 family. Result： The blood routine derived inflammatory indexes of group A， B， C and D were significantly higher than those of group E， those of group A， B and C were significantly higher than those of group D， those of group A and B were significantly higher than those of group C， and those of group A were significantly higher than those of group B， the differences were statistically significant （P<0.05）. The costimulation molecule B7 family in group A， B， C and D were significantly lower than those in group E， those in group A， B and C were significantly lower than those in group D， those in group A and B were significantly lower than those in group C， and those in group A were significantly lower than those in group B， the differences were statistically significant （P<0.05）. Pearson correlation analysis showed that NLR， PLR， NMLR， dNLR were negatively correlated with costimulation molecule B7 family 3 （B7-H3） and costimulation molecule B7 family 4 （B7-H4） in SLE patients （P<0.05）. Conclusion： The expression of blood routine derived inflammatory indexes and costimulation molecule B7 family is significantly abnormal in patients with systemic lupus erythematosus， and there is a close relationship between the above indicators.

[Key words] Blood routine derived inflammatory indexes Costimulation molecule B7 family Systemic lupus erythematosus Disease activity

First-author's address： Department of Laboratory， Dangyang People's Hospital， Dangyang 444100， China

doi：10.3969/j.issn.1674-4985.2024.08.032

系统性红斑狼疮的临床危害较大，可对患者的多系统器官造成损害，因此本病是临床研究较多的一个疾病。而众多与本病相关的研究显示，本类患者除表现出多系统器官损害及发热、光敏感、皮疹等表现外，其血液指标也呈现显著失衡的状态[1-2]。免疫炎症作为本病患者表现突出的方面，相关的指标在本类患者中的研究较多，中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、中性粒细胞与单核细胞之和/淋巴细胞比值（NMLR）及衍生的中性粒细胞/淋巴细胞比值（dNLR）等血常规衍生炎症指标可有效反映机体炎症状态。……