穆丹 陈荣娟 陈霞

【摘要】 目的：探究血必凈注射液在重症肺炎患者中的应用效果及对氧代谢、Toll样受体的影响。方法：将2019年12月—2023年1月辽阳市中心医院收治的100例重症肺炎患者根据随机数字表法分为对照组（n=50）和观察组（n=50）。对照组进行常规肺炎治疗，观察组则在对照组的基础上加用血必净注射液。比较两组治疗总有效率和治疗前后的炎症因子[C反应蛋白（CRP）、降钙素原（PCT）及白细胞计数（WBC）]、氧代谢指标[氧供（DO2）、氧耗（VO2）、氧供指数（DO2I）及氧耗指数（VO2I）]、Toll样受体[Toll样受体2（TLR2）及Toll样受体4（TLR4）]。结果：观察组治疗总有效率显著高于对照组，差异有统计学意义（P<0.05）；治疗前两组炎症因子、氧代谢指标及Toll样受体比较，差异均无统计学意义（P>0.05）；治疗1、2周后，观察组炎症因子及Toll样受体均显著低于对照组，氧代谢指标均显著高于对照组，差异均有统计学意义（P<0.05）。结论：血必净注射液在重症肺炎患者中的应用效果较好，可显著改善患者的氧代谢，下调Toll样受体表达。

【关键词】 血必净注射液 重症肺炎 氧代谢 Toll样受体

Application Effect of Xuebijing Injection in Patients with Severe Pneumonia and Its Influence on Oxygen Metabolism and Toll Like Receptor/MU Dan， CHEN Rongjuan， CHEN Xia. //Medical Innovation of China， 2024， 21（07）： -122

[Abstract] Objective： To investigate the application effect of Xuebijing Injection in patients with severe pneumonia and its influence on oxygen metabolism and Toll like receptor. Method： A total of 100 patients with severe pneumonia admitted to Liaoyang City Central Hospital from December 2019 to January 2023 were divided into control group （n=50） and observation group （n=50） according to random number table method. The control group received routine treatment for pneumonia， and the observation group received Xuebijing Injection on the basis of the control group. The total effective rate and before and after treatment of inflammatory factors [C reactive protein （CRP）， procalcitonin （PCT） and white blood cell count （WBC）]， oxygen metabolism indexes [oxygen delivery （DO2）， oxygen consumption （VO2）， oxygen delivery index （DO2I） and oxygen consumption index （VO2I）] and Toll like receptor [Toll like receptor 2 （TLR2）， Toll like receptor 4 （TLR4）] were compared between the two groups. Result： The total effective rate of the observation group was significantly higher than that of the control group， the difference was statistically significant （P<0.05）. Before treatment， there were no significant differences in inflammatory factors， oxygen metabolism indexes and Toll like receptor between the two groups （P>0.05）. After 1 week and 2 weeks of treatment， inflammatory factors and Toll like receptor in observation group were significantly lower than those in control group， and oxygen metabolism indexes were significantly higher than those in control group， the differences were statistically significant （P<0.05）. Conclusion： Xuebijing Injection has good application effect in patients with severe pneumonia， which can significantly improve oxygen metabolism and down-regulate Toll like receptor expression.

[Key words] Xuebijing Injection Severe pneumonia Oxygen metabolism Toll like receptor

First-author's address： Department of Respiratory and Critical Care， Liaoyang City Central Hospital， Liaoyang 111000， China

doi：10.3969/j.issn.1674-4985.2024.07.028

肺炎是临床常见呼吸系统感染性疾病，其中重症肺炎的危害较大，可危及患者的生命安全，是临床防控与诊治重视程度极高的一类疾病。临床中与重症肺炎相关的诊治研究显示，本病患者除C反应蛋白（CRP）、降钙素原（PCT）及白细胞计数（WBC）等炎症因子表达显著异常外，氧代谢在本类患者中也呈现较差的状态[1-2]，而Toll样受体作为与病原体侵入所致免疫应激密切相关的指标，其与本病的变化转归密切相关[3-5]。临床中采用血必净注射液治疗重症肺炎的研究可见，但是其细致效果研究不足。因此本研究现探究血必净注射液在重症肺炎患者中的应用效果及对氧代谢、Toll样受体的影响，并报道如下。……