韩乐乐 陆彩凤 缪晓杰 李道鸿

【摘要】 目的：探究強化营养联合抗阻运动训练对老年肌少症患者肌肉功能、炎症因子的影响。方法：选取2021年3月—2023年3月苏州市第九人民医院纳入的100例老年肌少症患者作为研究对象，随机选取50例患者为对照组，另外50例患者为观察组。对照组实施常规营养支持，观察组实施强化营养联合抗阻运动训练。比较干预后两组的肌肉功能[四肢骨骼肌质量指数（ASMI）、握力、6分钟步行试验（6MWT）]、炎症因子[白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）]及满意度。结果：干预后，观察组ASMI、握力、6MWT均优于对照组，差异均有统计学意义（P<0.05）。干预前，两组的IL-6、TNF-α、IL-1β水平比较，差异均无统计学意义（P>0.05）；干预后，观察组IL-6、TNF-α、IL-1β水平均低于对照组，差异均有统计学意义（P<0.05）。观察组的总满意度显著高于对照组，差异有统计学意义（P<0.05）。结论：强化营养联合抗阻运动训练对老年肌少症患者肌肉功能、炎症因子的影响较为显著。

【关键词】 强化营养联合抗阻运动训练 老年肌少症 肌肉功能 炎症因子

The Impact of Intensive Nutrition Combined with Resistance Exercise Training on Muscle Function and Inflammatory Factors in Elderly Patients with Sarcopenia/HAN Lele， LU Caifeng， MIAO Xiaojie， LI Daohong. //Medical Innovation of China， 2024， 21（08）： -120

[Abstract] Objective： To explore the impact of intensive nutrition combined with resistance exercise training on muscle function and inflammatory factors in elderly patients with sarcopenia. Method： A total of 100 elderly patients with sarcopenia admitted to Suzhou Ninth People's Hospital from March 2021 to March 2023 were selected for the study， 50 patients were randomly chosen for the control group and another 50 for the observation group. The control group received routine nutritional support， while the observation group received intensive nutritional combined with resistance exercise training. The muscle function [appendicular skeletal muscle index （ASMI）， grip strength， 6-minute walking test （6MWT）]， inflammatory factors [Interleukin-6 （IL-6）， tumor necrosis factor-alpha （TNF-α）， interleukin-1β （IL-1β）]， and satisfaction levels of the two groups after the intervention were compared. Result： After intervention， the ASMI， grip strength， and 6MWT in the observation group were better than those in the control group， the differences were statistically significant （P<0.05）. There were no significant differences in the levels of IL-6， TNF-α， and IL-1β between the two groups before intervention （P>0.05）; after intervention， the levels of IL-6， TNF-α， and IL-1β in the observation group were lower than those in the control group， the differences were statistically significant （P<0.05）. The total satisfaction in the observation group was significantly higher than that in the control group， the difference was statistically significant （P<0.05）. Conclusion： Intensive nutrition combined with resistance exercise training has a significant impact on muscle function and inflammatory factors in elderly patients with sarcopenia.

[Key words] Intensive nutrition combined with resistance exercise training Elderly sarcopenia Muscle function Inflammatory factors

First-author's address： Department of Geriatrics， Suzhou Ninth People's Hospital， Suzhou 215200， China

doi：10.3969/j.issn.1674-4985.2024.08.026

老年肌少症，又称肌萎缩，是一种与年龄有关的疾病，特点是肌肉质量的减少和功能的衰退，这一病状不仅影响患者的日常生活质量，还可能引起多种健康问题，包括减少的活动能力、增加的跌倒风险和身体功能下降等[1]。随着人口老龄化的不断加剧，老年肌少症的问题愈发凸显，已成为影响老年人健康和生活质量的重要因素之一[2]。在老年肌少症的干预措施中，营养支持和运动训练是两个重要方面。营养方面，特别是强化营养，通过补充高质量蛋白质和必需营养素，有助于改善肌肉质量和功能，强化营养不仅可以增加肌肉合成，还可以减少肌肉分解，有助于肌肉重建和恢复[3]。运动训练，特别是抗阻运动训练，是另一个关键因素。……