段芳芝 杨得军

【摘要】 目的：探讨自体角膜缘干细胞移植术、翼状胬肉切除术联合治疗翼状胬肉患者的效果。方法：从南平市第二医院2021年1月—2023年1月诊治的翼状胬肉患者中选择80例为观察对象，根据住院号单双数将其分为两组，每组40例，其中用翼状胬肉切除术治疗的为对照组，自体角膜缘干细胞移植术、翼状胬肉切除术治疗的为研究组。对比两组术前后的裸眼视力、屈光度及泪膜破裂时间（BUT）、泪液分泌试验（SIT）结果数值，统计两组并发症情况。结果：研究组术后裸眼视力与BUT、SIT结果数值均大于对照组，差异均有统计学意义（P<0.05）；研究组屈光度小于对照组，差异有统计学意义（P<0.05）；研究组并发症发生率低于对照组，差异有统计学意义（P<0.05）。结论：在翼状胬肉患者中联合应用翼状胬肉切除术、自体角膜缘干细胞移植术进行治疗，术后能够改善裸眼视力及屈光度，有利于泪膜功能恢复正常，且安全性较高。

【关键词】 自体角膜缘干细胞移植术 翼状胬肉切除术 翼狀胬肉

Effect of Autologous Limbal Stem Cell Transplantation Combined with Pterygium Excision in Treatment of Pterygium Patients/DUAN Fangzhi， YANG Dejun. //Medical Innovation of China， 2024， 21（07）： 0-031

[Abstract] Objective： To investigate the effect of limbal stem cell transplantation combined with pterygium excision in treatment of pterygium patients. Method： Eighty patients with pterygium treated in No.2 Hospital of Nanping City from January 2021 to January 2023 were selected as the observation objects and divided into two groups according to the number of hospitalization numbers， with 40 cases in each group. Among which the control group was treated with pterygium resection and the study group was treated with autologous limbal stem cell transplantation and pterygium resection. The naked eye visual acuity， diopter， results of breakup time of tear film （BUT） and Schirmer test （SIT） of the two groups were compared before and after surgery， and the complications of the two groups were analyzed. Result： The naked eye visual acuity， BUT and SIT results of the study group were higher than those of the control group， the differences were statistically significant （P<0.05）. The diopter of the study group was lower than that of the control group， the difference was statistically significant （P<0.05）. The complication rate of the study group was lower than that of the control group， the difference was statistically significant （P<0.05）. Conclusion： Combined pterygium excision and autologous limbal stem cell transplantation in patients with pterygium can improve naked eye vision and diopter after surgery， and is beneficial to restore normal tear film function， with high safety.

[Key words] Limbal stem cell autotransplantation Pterygium excision Pterygium

First-author's address： Ophthalmology Department， No.2 Hospital of Nanping City， Nanping 354200， China

doi：10.3969/j.issn.1674-4985.2024.07.007

翼状胬肉属于临床常见的眼表疾病，以局部球结膜纤维血管组织为主要临床表现，随着病情的进展，会发展至角膜，遮盖瞳孔，引起角膜散光等屈光异常，最终视力下降[1]。目前，临床上治疗该疾病的术式往往为翼状胬肉切除术，可彻底切除病灶，恢复眼部正常功能，但术式远期效果不理想，在切除后的伤口遗留会使术后复发率和并发症均较高[2-3]。因此，针对翼状胬肉患者，在翼状胬肉切除术后还需为其提供安全、有效的移植术加强临床效果。相关研究指出[4-5]，自体角膜缘干细胞移植术能为病变部位提供上皮，使术区损伤减轻，对角膜功能恢复有利，且不会损伤眼表结构及组织功能，有助于术后恢复，将其与翼状胬肉切除术联合应用，可获得良好的临床治疗效果。为此，本研究从南平市第二医院2021年1月—2023年1月诊治的翼状胬肉患者中选择80例为观察对象，分析自体角膜缘干细胞移植术、翼状胬肉切除术联合治疗的效果，报告如下。……