张岩 胡凤鸣 甘金林

【摘要】 目的：探討在扁平疣患者中应用祛疣汤联合维A酸乳膏外用治疗的效果。方法：选取2019年7月-2021年7月江西省皮肤病专科医院收治84例扁平疣患者，采用随机数字表法将其分为对照组和观察组，每组42例。对照组予以维A酸乳膏外用治疗，观察组在对照组的基础上加用祛疣汤治疗。比较两组临床疗效、皮损评分、T淋巴细胞亚群水平及不良反应发生情况。结果：观察组总有效率高于对照组，差异有统计学意义（P<0.05）。治疗后，两组皮损数量、瘙痒程度、皮损大小和皮损厚度评分均低于治疗前，且观察组均低于对照组，差异均有统计学意义（P<0.05）。治疗后，两组CD3+、CD4+、CD4+/CD8+水平均高于治疗前，且观察组均高于对照组，差异均有统计学意义（P<0.05）。两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：维A酸乳膏外用治疗扁平疣基础上联合祛疣汤口服，可减轻皮损症状，调节免疫功能，是一种安全、可靠的治疗方案。

【关键词】 扁平疣 祛疣汤 维A酸乳膏 皮损 免疫功能

Observation on the Effect of Quyou Decoction Combined with Tretinoin Cream for External Use in the Treatment of Flat Warts/ZHANG Yan， HU Fengming， GAN Jinlin. //Medical Innovation of China， 2022， 19（16）： -168

[Abstract] Objective： To investigate the effect of Quyou Decoction combined with Tretinoin Cream for external use in patients with flat warts. Method： A total of 84 patients with flat warts in Dermatology Hospital of Jiangxi Province from July 2019 to July 2021 were selected， they were divided into control group and observation group according to random number table， with 42 cases in each group. The control group was treated with Tretinoin Cream externally， and the observation group was treated with Quyou Decoction on the basis of the control group. The clinical efficacy， skin lesion score， T lymphocyte subgroup level and adverse reactions were compared between two groups. Result： The total effective rate of the observation group was higher than that of the control group， the difference was statistically significant （P<0.05）. After treatment， the number of skin lesions， itching degree， size and thickness scores of skin lesions of both groups were lower than those before treatment， and those of the observation group were lower than those of the control group， the differences were statistically significant （P<0.05）. After treatment， the levels of CD3+， CD4+ and CD4+/CD8+ of both groups were higher than those before treatment， and those of the observation group were higher than those of the control group， the differences were statistically significant （P<0.05）. There was no significant difference in the incidence of adverse reactions between two groups （P>0.05）. Conclusion： The external use of Tretinoin Cream combined with Quyou Decoction in the treatment of flat warts can reduce the symptoms of skin lesions and regulate the immune function， it is a safe and reliable treatment plan.

[Key words] Flat warts Quyou Decoction Tretinoin Cream Skin lesions Immune function

First-author’s address： Dermatology Hospital of Jiangxi Province， Nanchang 330000， China

doi：10.3969/j.issn.1674-4985.2022.16.040

扁平疣是皮肤科常见病，好发于青少年及免疫力低下人群，由人乳头状瘤病毒（HPV）感染所致，表现为褐色扁平丘疹，常见于颜面、手臂等部位，影响外貌美观[1-2]。扁平疣具有病程长、治疗困难、复发率高等特点，长期疾病折磨会对患者身心健康和生活质量造成极大影响[3-4]。当前扁平疣的西医治疗手段以调节免疫功能及抗病毒药物为主，但受个体间差异影响，疗效参差不齐，整体治疗效果欠佳。近年来，中医学关于扁平疣的治疗积累了丰富的经验，尤其是中医药治疗被广泛应用于临床治疗中，在改善临床症状方面表现出一定的优势。……