黄燕 刘馨

摘 要：为了更好地证明基于海藻酸钠的胶粘剂可以作为固定骨碎块的一种新型、先进的胶粘剂，现将海藻酸钠作为胶粘剂，开展固定骨碎块体外实验和动物实验。体外实验主要使用了猪股骨，并测量在不同时间段测量其于生理盐水中的剪应力。动物实验主要使用了大白兔实验材料，设置了对照组、空白组和实验组、并对其进行血生化检测、X线片拍摄。体外实验结果表明：基于海藻酸钠的胶粘剂完全可以固定在面积为1cm2的骨碎块中。动物实验结果表明：血生化检测后，发现术后3d、7d、14d的对照组和实验组在碱性磷酸酶方面没有明显的差异;X线片拍摄后，发现空白组和实验组均出现了明显移位现象，对照组骨折愈合时间类似;利用肉眼观察后，发现实验组的骨痴质量较低，出现针孔样腔隙现象。

关键词：海藻酸钠;胶粘剂;骨碎块固定;实验应用

中图分类号：TQ436 文献标识码：A     文章编号：1001-5922（2021）10-0018-04

Research on the Application of Adhesive Based on Sodium Alginate in the Fixation of Bone Fragments

Huang Yan ， Liu Xin

（Department of Surgery， Shiyan Maternal and Child Health Hospital， Shiyan 442000， China ）

Abstract：In order to better prove that the adhesive based on sodium alginate can be used as a new and advanced adhesive for fixation of bone fragments， sodium alginate is used as the adhesive to carry out in vitro and animal experiments on fixing bone fragments. In vitro experiment， pig femur was used to measure the shear stress in physiological saline at different time periods. The experimental materials of rabbits were used in animal experiments， including control group， blank group and experimental group， and performed blood biochemical testing and X-ray filming. The results of in vitro experiments show that the adhesive based on sodium alginate can be completely fixed in bone fragments with an area of 1cm2. The results of animal experiments showed that： after the blood biochemical test， it was found there was no significant difference in alkaline phosphatase between the control group and the experimental group at 3， 7 and 14 days after operation; after X-ray film was taken， it was found that there was obvious displacement in the blank group and the experimental group， and the fracture healing time in the control group was similar; by naked eye observation， it was found that the quality of bone in the experimental group was low and pinhole like lacuna appeared.

Key words：sodium alginate; adhesive; bone fragment fixation; experimental application

0 引言

最近幾年，在交通运输行业的不断发展下，粉碎性骨折类车祸事件屡见不鲜。对于骨碎块而言，其常用固定方法主要以缝合线捆扎固定法为主。但是，这种固定方法存在操作难度大、固定效果差、骨不连等问题。而基于海藻酸钠的胶粘剂出现和应用可以很好地解决这一问题，通过利用这种新型的胶粘剂，不仅可以提高骨碎块的粘合力，还能提高体内吸收能力，降低毒性。因此，如何将基于海藻酸钠的胶粘剂应用骨碎块固定中是相关人员必须思考和解决的问题。……