梁元钰 吕晓东 庞立健 董野 王佳然 张浩洋 史雁南 盛野

摘要 目的：对《素问·咳论》所载咳类疾病进行本体网络构建，实现咳类疾病的病因病机、临床表现和治疗穴位间关系的可视化表达，辅助厘清咳类疾病的临床诊疗体系。方法：基于《素问·咳论》原文提取节点和边，构建咳类疾病诊疗网络数据库后，导入Gephi 0.9.2软件中进行复杂网络分析。依次进行统计、排序、分割等外观处理，最终以网络图的形式具象化展示咳类疾病的诊疗关系。结果：建立含有76个节点的节点库及含有167条边（244次逻辑关系）的边库，并据此绘制出咳类疾病诊疗网络图。该网络以五脏六腑咳为主体，“肺”“胃”节点的加权度及节点连接的边的权重均高居前列，“寒”在病因节点中加权度较高，“太渊”“足三里”在治疗穴位节点中加权度较高。结论：咳是肺之本症，但五脏六腑皆可犯肺作咳。“聚于胃，关于肺”是对咳类疾病病机的高度概括，临床诊疗中应重视“气之本”肺和“五脏之本”胃。治疗时应当重视太渊和足三里2个穴位。同时，根据治未病理论，应注意既病防变，预防疾病向表里之腑和三焦传变。

关键词 咳;网络;素问·咳论;节点;边;Gephi软件;聚于胃，关于肺;五脏六腑皆令人咳

Abstract Objective：To construct ontology network for cough based on Suwen Kelun，and visualize the expression of the etiology，pathogenesis，clinical manifestations，and therapeutic acupoints of cough.Methods：Extracted nodes and edges based on the original text of Suwen Kelun were extracted，the database for diagnosis and treatment of cough was constructed，and then we imported it into Gephi 0.9.2 software to perform complex network diagram.And we conducted appearance processing such as statistics，sorting，and segmentation.Finally，the network diagram was formed to concretely show the relationship between diagnosis and treatment of cough by network diagram.Results：The node database with 76 nodes and the edge database with 167 edges（244 times of logical relationship）were established.Based on this，we draw a network diagram of the diagnosis and treatment of cough diseases.The network was mainly composed of five internal organs coughs and the six hollow organs coughs.The weight degree of the ‘lung and ‘stomach nodes and the weights of their connected edges were both at the forefront.The weight degree of ‘cold was high in the nodes about the cause，and ‘Taiyuan（LU9） and ‘Zusanli（ST36） were high in the nodes about the therapeutic points.Conclusion： Cough is the original disease of the lung， but all the viscera can cause cough. “Gathered in the stomach and connected with the lung” highly generalizes the pathogenesis of cough. In clinical diagnosis and treatment， we must pay attention to the lung， “root of qi”， and the stomach， “root of five zang viscera”. In the treatment， we must also pay attention to Taiyuan （LU9） and Zusanli （ST36）. Moreover， based on the preventive treatment theory， we need to notice the disease development and transmission， as well as prevent diseases from spreading to other viscera and the sanjiao.

Keywords Cough; Network; Suwen Kelun; Nodes; Edges; Gephi software; Gathered in the stomach; Viscera leading to cough

中圖分类号：R282文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.14.022

《黄帝内经》是中国现存最早的中医古籍，富含中国传统哲思，非一时一人之作，以黄帝与岐伯对话的形式，记录了古代先民与疾病斗争的经验，被誉为“治病的法书”[1-2]。《黄帝内经》奠定了中医学生理、病理、诊断以及治疗的认识基础，对临床疾病诊治有着重要的指导意义。……