相婧婧

[关键词] 硫酸镁;拉贝洛尔;妊娠高血压;妊娠结局

[中图分类号] R714.2          [文献标识码] B          [文章编号] 1673-9701（2021）19-0082-03

Efficacy of magnesium sulfate combined with labetalol in the treatment of pregnancy-induced hypertension and its influence on pregnancy outcome

XIANG Jingjing

Department of Obstetrics and Gynecology， Shuyang Hospital Affiliated to Xuzhou Medical University（Shuyang People′s Hospital）， Shuyang 223600， China

[Abstract] Objective To explore the therapeutic effect of magnesium sulfate combined with labetalol and its influence on pregnancy outcome in patients with pregnancy-induced hypertension. Methods A total of 56 patients with pregnancy-induced hypertension admitted to our hospital from January 2018 to December 2019 were randomLy divided into the observation group （28 cases treated with magnesium sulfate combined with labetalol） and the control group （28 cases treated with magnesium sulfate treatment）. The clinical efficacy and maternal and infant outcome after treatment was observed. Results The systolic blood pressure of the observation group was （135.61±6.24）mmHg， lower than the control group′s （142.62±8.75）mmHg.The diastolic blood pressure of the observation group was （86.63±4.19）mmHg，lower than the control group′s （92.47±5.86）mmHg. The total effective rate of treatment was The total effective rate of treatment in the observation group was 92.86%， which was significantly higher than 67.86% in the control group. The incidence of cesarean section， premature delivery， and postpartum hemorrhage of the observation group were 17.86%， 7.14%， and 10.71%， which were lower than those （50.00%， 35.71%， and 38.28%） of the control group. The incidence of fetal asphyxia and intrauterine distress of the observation group was 0.00% and 7.14%， respectively，lower than those （21.43% and 32.14%） of the control group， and the difference was statistically significant（P<0.05）.There was no significant difference in the incidence of fetal death between the two groups（P>0.05）. Conclusion Magnesium sulfate combined with labetalol can effectively control the blood pressure of patients with pregnancy-induced hypertension， improve the total effective rate of clinical treatment， and improve the maternal and infant outcome.

[Key words] Magnesium sulfate; Labetalol; Regnancy-induced hypertension; Pregnancy outcome

妊娠高血壓是妊娠期妇女常见的并发症之一，在妊娠20周后发生率较高，约为10%，与孕妇年龄、所处环境、疾病史、营养状况及精神状态关系密切[1-2]。临床常表现为头晕、头痛、血压升高、恶心呕吐、蛋白尿及水肿等，严重时会引发抽搐、昏迷等恶性症状，易发生早产、剖宫产、产后出血及胎儿宫内窘迫、窒息等不良妊娠结局，进而威胁母婴生命安全[3]。妊娠高血压患者因其处于特殊阶段，治疗需多方面考虑及综合评估[4]。硫酸镁是临床治疗妊娠高血压的常用药物，其作用主要是增加镁离子含量，拮抗镁离子释放及阻滞神经传导、松弛骨骼肌及镇静作用[5]。但单一用药效果相对局限，用量过多甚至会引发镁离子中毒，影响预后结局，所以需采取其他药物联合治疗[6]。本研究探讨硫酸镁联合拉贝洛尔治疗妊娠高血压的临床效果，现报道如下。