卢桐 国钰妍 张洪春 王雪京 李颖 屈毓敏

摘要 目的：观察应用疏风解痉理论组方的苏黄止咳汤治疗变应性咳嗽（风邪犯肺证）患者的临床疗效。方法：选取2015年10月至2018年9月北京市宣武中医医院收治的变应性咳嗽（风邪犯肺证）患者66例作为研究对象，按照随机数字表法分为对照组和观察组，每组33例。对照组给予开瑞坦治疗;观察组给予苏黄止咳汤治疗，观察2组患者治疗2周中医证候积分及疾病疗效，血清IgE计数改善程度，并评估停药4周疾病复发率。结果：治疗后，观察组与对照组的总有效率分别为84.9%和78.8%，差异有统计学意义（P<0.05）;观察组血清IgE计数改善优于对照组，差异有统计学意义（P<0.05）。结论：应用疏风解痉理论的苏黄止咳汤能有效地缓解变应性咳嗽患者的临床症状;值得进一步推广及应用。

关键词 变应性咳嗽;疏风解痉法;苏黄止咳汤

Abstract Objective：To observe the clinical efficacy of Suhuang Zhike Decoction with the theory of Shufeng Jiejingtang in the treatment of patients with allergic cough（the syndrome of wind pathogen invading the lung）.Methods：A total of 66 patients with allergic cough（wind evil invades the lung syndrome） who were admitted to Beijing Xuanwu Hospital of Traditional Chinese Medicine from October 2015 to September 2018 were selected as the research objects.According to the random number table method，they were divided into a control group and an observation group，with 33 cases in each group.The control group was treated with Kairuitan; and the observation group was treated with Suhuang Zhike Decoction.The scores of TCM syndromes and disease efficacy of the two groups of patients after two weeks of treatment，and the degree of improvement in serum IgE counts were observed，and the recurrence rate of the disease for 4 weeks after stopping the drug were evaluated.Results：After treatment，the total effective rates of the observation group and the control group were 84.9% and 78.8%，respectively，and the difference was statistically significant（P<0.05）; the improvement in serum IgE counts in the observation group was better than that of the control group，and the difference was statistically significant（P<0.05）.Conclusion：Suhuang Zhike Decoction based on dispelling wind and relieving spasm method can effectively relieve the clinical symptoms of atopic cough，which is worthy of further promotion and application.

Keywords Atopic cough; Dispelling wind and relieving spasm method; Suhuang Zhike Decoction

中圖分类号：R256.11;R242文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.11.020

变应性咳嗽（Atopic Cough，AC）是一种变态反应性疾病，临床表现为变应性非哮喘性、慢性或咽痒等引起的阵发性刺激性干咳，肺功能正常，无气道高反应性[1];其占慢性咳嗽患者的12%左右，是慢性咳嗽的主要病因之一[2]。目前，关于AC发病的机制尚未明确，可能与环境、炎症、真菌定植、咳嗽功能紊乱等有关[3-5]，临床上，多采用抗组胺药或糖皮质激素治疗，虽可缓解部分症状，但有很高的复发率，远期疗效并不理想[6]。中医在咳嗽方面有着悠久的历史与经验，从中医角度治疗AC有着较大的优势。中医将AC归为“顽咳”“风咳”的范畴，治疗应以扶正祛邪为主[7]，国医大师晁恩祥对表现为刺激性干咳的慢性咳嗽，从风论治，提出以疏风解痉、宣肺止咳为主的治疗原则[8-9]。我们以疏风解痉、宣肺止咳为法，应用苏黄止咳汤治疗风邪犯肺型变应性咳嗽患者，临床疗效显著。……