张佳河 李惠

【摘 要】 目的：研究中医药治疗便秘型肠易激综合征（IBS-C）用药规律。方法：使用检索词，查找并筛选中国期刊全文数据库（CNKI）中2000年1月至2020年3月中医药治疗IBS-C的有效处方，用EXCEL表格建立数据库，对其进行频数分析、关联规则分析和聚类分析。 结果：共筛选出治疗IBS-C的方剂94首，涉及中药115味，总频次为916次，频次≥10有24味中药，其中甘草，白术，白芍频次最高;药物类别以补虚药和理气药为主;四气以温、寒、平为主;五味以苦、辛、甘药物为主;归经以脾、胃、肺、肝为主。结论：治疗IBS-C以健脾疏肝治其本，以清热祛瘀、化痰消积治其标，扶正祛邪，辨证论治。

【关键词】 便秘型肠易激综合征;中医药;用药规律;数据挖掘

【中图分类号】R259   【文献标志码】 A    【文章编号】1007-8517（2021）12-0009-05

Abstract：Objective To study the prescription rule of traditional Chinese medicine （TCM） in the treatment of constipation predominant irritable bowel syndrome （IBS-C）.Methods The effective prescriptions of TCM treatment of IBS-C were searched and selected in CNKI from January 2000 to March 2020，using the EXCEL form to establish the database，and they were given frequency analysis，association rules analysis and cluster analysis.Results A total of 94 prescriptions were selected，including 115 herbs，and the frequency of use was 916 and 24 herbs were used for more than 10 times. The top three highest frequency of use were Radix Glycyrrhizae，Rhizoma Atractylodis Macrocephalae and Radix Paeoniae Alba. The category of herbs were mainly Invigorating deficiency drugs and Qi-regulating drugs. The medicinal properties were mainly warm，cold and calm. The five favors were mainly bitter，spicy and sweet. The meridian attribution was mainly based on the spleen，stomach，lung and liver. Conclusion The treatment of IBS-C is strengthening spleen，soothing liver to treat the root，treating the branch through clearing away heat，removing blood stasis，resolving phlegm and eliminating accumulation. The therapeutic principal is strengthening body resistance and eliminating？evil and is based on syndrome differentiation and treatment.

Keywords：Constipation Predominant Irritable Bowel Syndrome;Traditional Chinese Medicine;Medication Rule;Data Mining

腸易激综合征（Irritable bowel syndrome，IBS）[1]是一种功能性肠胃病，临床以反复腹痛伴排便习惯改变为主要特征，根据罗马Ⅳ标准分为四个亚型：便秘型、腹泻型、混合型和不定型。便秘型肠易激综合征（IBS-C）[2] 以腹胀腹痛、大便秘结、排便困难和次数减少为主要表现，属于中医“便秘”“气秘”“腹痛”的范畴，主要证素有肝实、脾虚、阴亏、湿热等，与肝、胃、脾、肾、大肠密切相关，其中“肝郁脾虚，气机失调”贯穿疾病发展的始终。IBS-C在IBS患病人群中可占36.5%，其影响因素较多，常迁延不愈，复发率较高，严重影响患者的生活[3]。研究发现，中医药治疗IBS-C有着较大的优势，在临床上取得可观疗效，本文通过研究中国知网相关文献，利用数据挖掘技术，探求总结中医药治疗IBS-C的用药规律。

1 资料和方法

1.1 资料来源 采用计算……