纪成波

[摘要] 目的 探讨奥美拉唑与兰索拉唑分别联合抗生素治疗酒精型消化溃疡的效果。 方法 选取我院2018年8月至2020年1月收诊的酒精型消化溃疡患者194例为研究对象，以电脑随机法分组，奥美拉唑组患者应用奥美拉唑联合抗生素治疗，兰索拉唑组患者应用兰索拉唑联合抗生素治疗，对比两组的治疗总有效率、临床症状消失时间、不良反应发生率等。 结果 奥美拉唑组患者治疗总有效率为86.60%，低于兰索拉唑组的96.91%，差異有统计学意义（P<0.05）;奥美拉唑患者的腹痛、嗳气、反酸、腹胀、呕吐症状消失时间均长于兰索拉唑组，差异有统计学意义（P<0.05）;奥美拉唑组患者的不良反应发生率为11.33%，高于兰索拉唑组的2.06%，差异有统计学意义（P<0.05）。结论 兰索拉唑联合抗生素疗法在酒精型消化溃疡患者治疗中应用疗效更好，有利于促进患者临床症状缓解，且用药安全性高，患者耐受力更好，值得推广。

[关键词] 奥美拉唑;兰索拉唑;抗生素;酒精型消化溃疡;不良反应;临床症状

[中图分类号] R573          [文献标识码] B          [文章编号] 1673-9701（2021）12-0059-04

Clinical efficacy of omeprazole and lansoprazole combined with antibiotics respectively in the treatment of alcoholic peptic ulcer

JI Chengbo

Department of Cardiology， Fengcheng Central Hospital in Liaoning Province， Fengcheng   118100， China

[Abstract] Objective To study the efficacy of omeprazole and lansoprazole combined with antibiotics respectively in the treatment of alcoholic peptic ulcer. Methods A total of 194 patients with alcohol-based digestive ulcer admitted to gastroenterology of our hospital from August 2018 to January 2020 were selected as the research objects and divided into the omeprazole group and the lansoprazole group according to the computer random method. The omeprazole group was treated with omeprazole combined with antibiotics， while the lansoprazole group was treated with lansoprazole combined with antibiotics. The total effective rate of treatment， the disappearance time of clinical symptoms and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the omeprazole group was 86.60%， which was lower than that of the lansoprazole group （96.91%），the difference was statistically significant（P<0.05）. The disappearance time of symptoms of abdominal pain， belching， acid reflux， abdominal distension and vomiting in omeprazole group was higher than that in the lansoprazole group， the difference was statistically significant（P<0.001）. The incidence of adverse reactions in the omeprazole group was 11.33%， which was higher than that in the lansoprazole group （2.06%）， the difference was statistically significant（P<0.05）. Conclusion Lansoprazole combined with antibiotics has a better effect in the treatment of patients with alcoholic peptic ulcer， which is conducive to promoting the remission of clinical symptoms in patients， with high safety and better tolerance. It is worthy of promotion.

[Key words] Omeprazole; Lansoprazole; Antibiotics; Alcoholic peptic ulcer; Adverse reactions; Clinical symptoms

酒精型消化溃疡（Alcohol-based peptic ulcers）是常见的一种消化性溃疡[1-2]，其发病诱因是饮酒过度，是长期、大量饮酒导致胃、十二指肠发生溃瘍的疾病，主要临床症状为嗳气、腹痛、腹胀等[3]，其疼痛的严重程度要显著高于常规的消化溃疡，且该病的持续时间长，会严重影响患者的正常生活、工作、学习，给患者带来较大痛苦。临床治疗中以抑酸、根除Hp为主，质子泵抑制剂联合抗生素的疗法是目前临床上最常用的应用方法，大部分患者疗效满意，而其中质子泵抑制剂发挥着重要作用，疗效已得到认可[4-5]。目前临床上的质子泵抑制剂品种多，奥美拉唑和兰索拉唑是应用率较高的两种质子泵抑制剂，但是关于二者在酒精型消化性溃疡中的疗效还存在一定争议，本研究选择常见的奥美拉唑和兰索拉唑为例，对比分析这两种质子泵抑制剂联合抗生素治疗酒精型消化溃疡的效果，现选取我院的194例酒精型消化溃疡患者为对象进行对照分析，现报道如下。……