康丽

【摘要】 目的：探討新生儿窒息与血清碱性磷酸酶、血25-羟维生素D3表达水平的相关性。方法：选取2017年8月-2020年8月本院收治的60例新生儿窒息患儿作为研究组，另选取同期60例健康新生儿作为对照组。对比两组新生儿血清相关指标、尿酶相关指标、肾主动脉血流参数指标表达水平，分析相关指标与新生儿窒息的相关性。结果：研究组血25-羟维生素D3、血清碱性磷酸酶均低于对照组，尿素氮、肌酐水平均高于对照组，差异均有统计学意义（P<0.05）。研究组ALP、GAL、GGT、NAG均高于对照组，差异均有统计学意义（P<0.05）。研究组PI、RI均高于对照组，EDFV、PSFV均低于对照组，差异均有统计学意义（P<0.05）。Spearman相关分析结果显示：血25-羟维生素D3、血清碱性磷酸酶、EDFV与新生儿窒息均呈负相关（P<0.05），尿素氮、肌酐、ALP、GAL、GGT、NAG、PI、RI与新生儿窒息均呈正相关（P<0.05），PSFV与新生儿窒息无相关性（P>0.05）。结论：血清指标检查、尿酶相关指标检查以及肾主动脉血流参数检查都能判断新生儿窒息情况，其中血清碱性磷酸酶与血25-羟维生素D3表达水平与新生儿窒息具有明显相关性，可以用于判断新生儿窒息严重情况与预后的判断，具有重要价值。

【关键词】 新生儿窒息 血清碱性磷酸酶 血25-羟维生素D3 相关性

Correlation between Neonatal Asphyxia and the Expression of Serum Alkaline Phosphatase and Blood 25 Hydroxyvitamin D3/KANG Li. //Medical Innovation of China， 2021， 18（05）： -158

[Abstract] Objective： To investigate the correlation between neonatorum asphyxia and the levels of serum alkaline phosphatase and blood 25 hydroxyvitamin D3. Method： A total of 60 cases of neonatal asphyxia in our hospital from August 2017 to August 2020 were selected as the study group， another 60 healthy newborns in the same period were selected as the control group. The expression levels of serum related indexes， urinary enzyme related indexes and renal aortic blood flow parameters were compared between the two groups， the correlation between related indexes and neonatal asphyxia was analyzed. Result： The levels of blood 25 hydroxyvitamin D3， alkaline phosphatase in the study group were lower than those in the control group， the levels of urea nitrogen and creatinine were higher than those in the control group （P<0.05）. ALP， GAL， GGT， NAG of the study group were higher than those of the control group， the differences were statistically significant （P<0.05）. PI and RI of the study group were higher than those of the control group， EDFV， PSFV were lower than those of the control group， the differences were statistically significant （P<0.05）. Spearman correlation analysis showed that： blood 25 hydroxyvitamin D3， serum alkaline phosphatase， EDFV there were a negative correlation between urea nitrogen， creatinine， ALP， GAL， GGT， NAG， PI， RI were positively correlated with neonatal asphyxia （P<0.05）， PSFV had no correlation with neonatal asphyxia （P>0.05）. Conclusion： Serum indicators， urine enzyme related indicators and renal aortic blood flow parameters can judge the situation of neonatal asphyxia， in which serum alkaline phosphatase and blood 25 hydroxyvitamin D3 expression levels are significantly correlated with neonatal asphyxia， which can be used to judge the severity and prognosis of neonatal asphyxia， has important value.

[Key words] Neonatal asphyxia Serum alkaline phosphatase Blood 25 hydroxyvitamin D3 Correlation

First-authors address： Jiangmen Maternal and Child Health Hospital， Jiangmen 529000， China

doi：10.3969/j.issn.1674-4985.2021.05.039

隨着新生儿科和妇产科临床诊治水平的不断提升，如围生期保健管理制度和服务措施的完善、高危妊娠产妇分娩前会诊、围生期新生儿窒息复苏方案制定和临床操作等，使得新生窒息发生率和窒息导致死亡的病例呈逐年下降趋势[1]。但新生儿窒息依旧是导致新生儿死亡、降低新生儿存活质量的主要原因。导致新生儿窒息发生的可能因素有胎儿脐带异常、胎儿宫内窘迫综合征、分娩过程中不顺利、母体本身缺氧等。新生儿窒息发病影响因素较多，相关研究显示，窒息程度与血清钙含量有一定关联[2-4]，血清钙含量与患儿预后情况也存在一定关联。……