刘欣金 龚立勤

【摘要】 目的：探讨乳腺癌化疗性肝损伤的相关危险因素。方法：选择2015年1月-2019年12月在本院接受化疗的106例乳腺癌患者的资料进行回顾性分析。对全部患者发生化疗性肝损伤的情况进行描述。按照患者是否发生化疗性肝损伤分组，分为病例组33例和对照组73例。通过单因素分析与多因素分析的方式，筛选乳腺癌化疗性肝损伤的相关危险因素。结果：2015年1月-2019年12月在本院接受化疗的乳腺癌患者共106例，33例患者发生化疗性肝损伤，发病率为31.13%。年龄、BMI、化疗方案、乙肝病毒感染、糖尿病是乳腺癌患者发生化疗性肝损伤的独立危险因素（P<0.05）。结论：多种因素均可导致乳腺癌患者出现化疗性肝损伤，需要进行具有针对性的干预。

【关键词】 乳腺癌 化疗性肝损伤 恶性肿瘤 毒副反应

Study on Risk Factors Associated with Chemotherapy-induced Liver Injury in Breast Cancer/LIU Xinjin， GONG Liqin. //Medical Innovation of China， 2021， 18（05）： -136

[Abstract] Objective： To investigate the risk factors associated with chemotherapy-induced liver injury in breast cancer. Method： The data of 106 breast cancer patients who received chemotherapy in our hospital from January 2015 to December 2019 were retrospectively analyzed. The occurrence of chemotherapy-induced liver injury in all patients were described. Patients were divided into case group （n=33） and control group （n=73） according to the occurrence of chemotherapy-induced liver injury. Univariate analysis and multivariate analysis were used to screen the risk factors of breast cancer chemotherapy-induced liver injury. Result： In January 2015 to December 2019， 106 patients received chemotherapy in our hospital， and 33 patients developed chemotherapy induced liver injury， the incidence rate was 31.13%. Age， BMI， chemotherapy regimen， hepatitis B virus infection and diabetes mellitus were independent risk factors for chemotherapy-induced liver injury in breast cancer patients （P<0.05）. Conclusion： Many factors can lead to chemotherapy-induced liver injury in patients with breast cancer， which needs targeted intervention.

[Key words] Breast cancer Chemotherapy-induced liver injury Malignant tumor Toxic side effects

First-authors address： Dongguan Kanghua Hospital， Dongguan 523000， China

doi：10.3969/j.issn.1674-4985.2021.05.034

乳腺癌是我國乃至全球范围内女性人群极为常见的一类恶性肿瘤，近年来随着我国人口数量的增加以及各种不良生活习惯等的共同影响，乳腺癌的发病例数以及死亡例数等逐渐增加，已经对女性人群健康构成严重威胁，甚至是导致人群健康寿命明显降低的主要原因之一[1-2]。根据近期的报道显示，全世界的女性人群中，每年乳腺癌的新发病例数超过160万，而其中接近60%的比例均为不发达国家以及地区的人群[3-4]。乳腺癌的研究历来就是医学界所关注的焦点，其治疗方式目前也存在手术、化疗、放疗以及靶向治疗等多种类型[5]。其中化疗属于研究的较为透彻的一类治疗方法，作为绝大多数乳腺癌患者所使用的治疗方式，化疗对于控制患者的病情发展，延长寿命以及维持生命质量方面起到值得肯定的效果[6]。……