刘伟玲 李伟文 李莉芬

[摘要] 目的 探討肺功能锻炼对肺癌术后化疗患者肺功能和癌因性疲乏改善的作用。 方法 选取2017年6月至2019年12月期间我院呼吸科和肿瘤科住院治疗肺癌术后化疗患者74例，随机分为干预组和对照组各37例。对照组患者予常规干预措施，干预组患者在对照组基础上予以肺功能锻炼，两组患者均干预8周。观察并比较两组患者干预前后肺功能指标和癌因性疲乏指标的变化。 结果 干预8周后，两组患者肺功能指标FEV1、FEV1/FVC和PEF较前明显上升（P<0.05或P<0.01），且治疗后干预组上升更明显（P<0.05）;同时两组患者各个维度PFS-R评分较前明显下降（P<0.05或P<0.01），且干预组下降更明显（P<0.05）。 结论  肺功能锻炼用于肺癌术后化疗患者不仅可改善肺功能，而且可缓解癌因性疲乏症状。

[关键词] 肺癌术后;化疗;肺功能锻炼;肺功能;癌因性疲乏

[中图分类号] R734.2          [文献标识码] A          [文章编号] 1673-9701（2021）08-0020-04

Effects of pulmonary function exercise on improving pulmonary function and cancer-related fatigue of postoperative chemotherapy patients with lung cancer

LIU Weiling1   LI Weiwen1   LI Lifen2

1.Department of Respiratory and Critical Care Medicine， Lishui Municipal Central Hospital in Zhejiang Province， Lishui   323000， China; 2.Department of Oncology， Lishui Municipal Central Hospital in Zhejiang Province， Lishui 323000， China

[Abstract] Objective To investigate the effects of pulmonary function exercise on improving pulmonary function and cancer-related fatigue of postoperative chemotherapy patients with lung cancer. Methods A total of 74 hospitalized patients with postoperative chemotherapy for lung cancer admitted to our hospital from June 2017 to December 2019 were selected and randomly divided into the intervention group（n=37） and the control group（n=37）. Patients in the control group were treated with conventional intervention measures， while patients in the intervention group were treated with pulmonary function exercise on the basis of the control group. Both groups were intervened for 8 weeks. The changes of pulmonary function indexes and cancer-related fatigue indexes before and after intervention were observed and compared. Results Eight weeks after intervention， the pulmonary function indexes FEV1， FEV1/FVC and PEF in the two groups were significantly higher than those before intervention（P<0.05 or P<0.01）. And after treatment， the patients in the intervention group increased significantly than those in the control group（P<0.05）. At the same time， PFS-R scores in all dimensions of patients in the two groups were significantly lower than those before intervention（P<0.05 or P<0.01）， and the decline of patients in the intervention group was decreased than that in the control group（P<0.05）. Conclusion Pulmonary function exercise can not only improve pulmonary function， but also relieve cancer-related fatigue symptoms.

[Key words] Postoperative lung cancer; Chemotherapy; Pulmonary function exercise; Pulmonary function; Cancer-related fatigue

肺癌作为一种呼吸内科较常见的肺部恶性肿瘤，近年来其发生率及病死率逐年升高，对患者的生命威胁较大[1]。手术+术后辅助化疗是治疗肺癌的主要手段，但由于肺叶的切除引起肺容量下降及开胸引起创伤，会影响患者的呼吸功能;同时癌症患者常伴有不同程度的癌因性疲乏，影响患者术后化疗继续进行[2，3]。以往临床上采用多种方法改善肺癌术后化疗患者肺功能及癌因性疲乏，但总体来说效果欠理想[4，5]。肺功能锻炼是针对慢性呼吸损伤患者制订的一系列强化呼吸肌、改善肺通气及换气功能的锻炼方法，但用于肺癌术后化疗患者国内鲜有报道[6-7]。本研究分析肺功能锻炼对肺癌术后化疗患者肺功能和癌因性疲乏改善的作用，现报道如下。

1 资料与方法

1.1 一般资料

选取2017年6月至2019年12月我院呼吸科和肿瘤科住院治疗肺癌术后化疗患者74例。……