王琴 朱齐琦

【摘要】 目的：探討布地奈德联合硫酸沙丁胺醇治疗老年哮喘患者的效果及对血清IL-4、IFN-γ水平的影响。方法：选取2019年10月-2020年10月本院收治的142例老年哮喘患者，按照随机数字法分为对照组和研究组，每组71例。对照组在常规治疗的基础上联合布地奈德雾化吸入进行治疗，研究组在对照组的基础上联合硫酸沙丁胺醇进行治疗。比较两组患者的临床治疗效果、血清炎症因子水平、肺功能、呼吸道症状评分、临床症状缓解时间和临床治疗安全性。结果：研究组总有效率高于对照组，差异有统计学意义（P<0.05）。治疗前，两组FEV1、FVC、PEF、IL-4、IFN-γ比较，差异均无统计学意义（P>0.05）;治疗后，研究组IFN-γ低于对照组，FEV1、FVC、PEF、IL-4水平均高于对照组，差异均有统计学意义（P<0.05）。治疗前，两组喘息、咳嗽、呼吸困难、哮鸣音评分比较，差异均无统计学意义（P>0.05）;治疗1周，研究组喘息、咳嗽、呼吸困难、哮鸣音评分均低于对照组，差异均有统计学意义（P<0.05）。研究组喘息、咳嗽、呼吸困难、哮鸣音缓解时间均短于对照组，差异均有统计学意义（P<0.05）。研究组不良反应发生率为11.3%低于对照组的33.8%，差异有统计学意义（P<0.05）。结论：采用布地奈德联合硫酸沙丁胺醇对老年哮喘患者进行治疗，可有效控制咳嗽、喘息等症状，同时降低呼吸道症状评分，提高临床治疗有效率，改善FVC、FEV1、PEF水平，降低IFN-γ水平，有利于患者的康复，值得在临床上推广应用。

【关键词】 哮喘 布地奈德 硫酸沙丁胺醇 炎症因子 肺功能

Effect of Budesonide Combined with Salbutamol Sulfate in the Treatment of Elderly Patients with Asthma and Its Influence on Serum IL-4 and IFN-γ/WANG Qin， ZHU Qiqi. //Medical Innovation of China， 2021， 18（29）： 0-049

[Abstract] Objective： To investigate the effect of Budesonide combined with Salbutamol Sulfate in the treatment of elderly patients with asthma and its influence on serum IL-4 and IFN-γ. Method： A total of 142 elderly patients with asthma treated in our hospital from October 2019 to October 2020 were selected， they were divided into control group and study group according to random number table method， 71 cases in each group. The control group was treated with Budesonide atomization inhalation on the basis of routine treatment， and the study group was treated with Salbutamol Sulfate on the basis of the control group. The clinical treatment effect， serum inflammatory factor level， pulmonary function， respiratory symptom score， clinical symptom remission time and clinical treatment safety were compared between two groups. Result： The total effective rate of the study group was higher than that of the control group， the difference was statistically significant （P<0.05）. Before treatment， there were no significant differences in FEV1， FVC， PEF， IL-4 and IFN-γ between two groups （P>0.05）; after treatment， the levels of IFN-γ of the study group were lower than those of the control group， and the levels of FEV1， FVC， PEF and IL-4 were higher than those of the control group， the differences were statistically significant （P<0.05）. Before treatment， there were no significant differences in scores of wheezing， coughing， dyspnea and wheezing between two groups （P>0.05）; 1 week of treatment， the scores of wheezing， coughing， dyspnea and wheezing of the study group were lower than those of the control group， the differences were statistically significant （P<0.05）. The remission time of wheezing， cough， dyspnea and wheezing of the study group was shorter than those of the control group， the differences were statistically significant （P<0.05）. The incidence of adverse reactions of the study group was 11.3%， which was lower than 33.8% of the control group， the difference was statistically significant （P<0.05）. Conclusion： Budesonide combined with Salbutamol Sulfate in the treatment of elderly patients with asthma can effectively control the symptoms of cough， wheezing and other symptoms， reduce the score of respiratory symptoms， improve the clinical treatment efficiency， improve the FVC， FEV1， PEF levels， reduce IFN-γ level， which is conducive to the rehabilitation of patients， and worthy of clinical application.

[Key words] Asthma Budesonide Salbutamol Sulfate Inflammatory factors Lung function

First-author’s address： The First People’s Hospital of Jiujiang City， Jiujiang 332000， China

doi：10.3969/j.issn.1674-4985.2021.29.011

支氣管哮喘属于气道慢性炎症疾病，也是最常见的诱发慢性咳嗽的因素之一，该疾病的发生需要多种炎性细胞、炎性介质共同参与，从而对人体造成强烈的刺激[1-3]。……