马占龙

【摘 要】目的：探究并分析氨茶堿对慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）稳定期患者的疗效。方法：选择2018年1月至2020年3月期间来我院治疗的70例慢阻肺患者作为研究的主体，将其随机分为两组（35例/组），对照组患者给予布地奈德治疗，观察组患者在布地奈德基础上加用氨茶碱治疗，对比两组的治疗效果、不良反应发生率及治疗前后的临床症状（咳嗽、咳痰、气短）改善情况。结果：观察组治疗有效率（94.29%，33/35）显著高于对照组（77.14%，27/35），数据比较有统计学差异；治疗前，两组的咳嗽、咳痰、气短症状评分比较接近，没有统计学意义（P>0.05）；治疗后，两组以上症状评分明显降低，且观察组降低幅度（0.93±0.19分、0.99±0.13分、1.01±0.16分）比对照组（1.23±0.25 分、1.23±0.14分、1.35±0.21分）更大（P<0.05）；观察组和对照组的不良反应发生率接近，分别为14.29%、8.57%，没有统计学意义（P>0.05）。结论：氨茶碱可提高慢阻肺稳定期患者的疗效，改善患者的临床症状，且不会显著增加不良反应发生率。

【关键词】氨茶碱；布地奈德；慢阻肺；临床症状；不良反应

Analysis of the effect of aminophylline on patients with stable chronic obstructive pulmonary disease

Ma Zhanlong Xining Chengdong District Dazhong Street Yuanshan Community Health Service Center， Xining Qinghai 810000，China

【Abstract】Objective： To explore and analyze the efficacy of aminophylline in patients with stable chronic obstructive pulmonary disease（COPD）. Methods： 70 patients with COPD treated in our hospital from January 2018 to March 2020 were selected and randomly divided into two groups （35 cases/group）. The control group was given budesonide treatment， and the observation group was given budesonide and aminophylline treatment， the treatment effect， incidence of adverse reactions and improvement of clinical symptoms （cough， expectoration and shortness of breath） before and after treatment were compared between the two groups. Results： The effective rate of the observation group （94.29%， 33/35） was significantly higher than that of the control group （77.14%， 27/35）； Before treatment， the scores of cough， expectoration and shortness of breath in the two groups were similar， with no statistical significance（P>0.05）； After treatment， the symptom scores of the two groups decreased significantly， and the decrease range of the observation group （0.93±0.19 points， 0.99±0.13 points， 1.01±0.16 points） was greater than that of the control group （1.23±0.25 points， 1.23±0.14 points， 1.35±0.21 points（P<0.05）； The incidence of adverse reactions in the observation group and the control group were similar， 14.29% and 8.57% respectively， with no statistical significance（P>0.05）. Conclusions： Aminophylline can improve the curative effect of patients with stable chronic obstructive pulmonary disease， improve the clinical symptoms of patients， and will not significantly increase the incidence of adverse reactions.

【Key？Words】aminophylline， budesonide， chronic obstructive pulmonary disease， clinical symptoms， adverse reactions

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者的临床典型症状为患者会出现持续的气流受限，病情呈进展态势，从而降低了患者肺功能，因此其治疗原则是改善患者的肺功能，临床上需采用合适的药物治疗[1]。氨茶碱具有止咳、松弛患者的呼吸道平滑肌、抗感染、祛痰等作用[2]，我院将其用于慢阻肺稳定期患者治疗中，治疗效果明确，报告如下。

1.1 一般资料

选择2018年1月至2020年3月期间来我院治疗的70例慢阻肺患者，所有患者均符合慢阻肺相关疾病诊断标准，且疾病处于稳定期；……