闫赋琴 徐善荣 邵明国 牟艳芳

摘要 目的：探討柴银口服液治疗小儿风热感冒的临床效果。方法：选取2020年7月至2020年12月中国人民解放军总医院医疗保障中心收治的风热感冒患儿120例作为研究对象，按照随机数字表法分为对照组和观察组，每组60例。对照组患儿口服利巴韦林颗粒，观察组患儿给予柴银口服液治疗。治疗3 d后，比较2组患儿临床疗效、临床症状缓解时间，并检测治疗前后免疫功能指标（CD4+、CD8+、CD4+/CD8+）和炎症介质白细胞介素-6（IL-6）、白细胞介素-8（IL-6）、肿瘤坏死因子-α（TNF-α）水平。结果：治疗后观察组治疗有效率高于对照组，差异有统计学意义（P<0.05）;观察组患儿高热、咳嗽、鼻塞流涕、寒战症状的缓解时间均短于对照组，差异均有统计学意义（均P<0.05）;观察组CD4+、CD4+/CD8+水平高于对照组，且CD8+低于对照组，差异均有统计学意义（均P<0.05）;观察组患儿IL-6、IL-8、TNF-α水平均低于对照组，差异均有统计学意义（均P<0.05）;2组患儿不良反应发生率比较差异无统计学意义（P>0.05）。结论：柴银口服液治疗小儿风热感冒的效果显著，有利于改善患儿临床症状，提高机体免疫力，缓解炎症反应，且具有良好的用药安全性。

关键词 柴银口服液;小儿风热感冒;利巴韦林颗粒;免疫功能;炎症介质;肿瘤坏死因子-α;炎症反应;安全性

Abstract Objective：To explore the clinical effect evaluation of Chaiyin Oral Liquid on children with wind-heat syndrome cold.Methods：A total of 120 children with wind-heat syndrome cold admitted to Medical Security Center of PLA General Hospital from July 2020 to December 2020 were selected as the research objects and were randomly divided into a control group and an observation group according to random number table method，with 60 cases in each group.The control group was given ribavirin granules orally，and the observation group was given Chaiyin Oral Liquid.After 3 days of treatment，compare the clinical efficacy and clinical symptom relief time of the two groups of children were compared，and detect the immune function indicators（CD4+，CD8+，CD4+/CD8+） and the levels of inflammatory factors [Interleukin-6（IL-6），Interleukin-8（IL-6），tumor necrosis factor-α（TNF-α）] were detected.Results：After treatment，the effective rate of treatment in the observation group was higher than that in the control group，and the difference was statistically significant（P<0.05）; the relief time of the symptoms of high fever，cough，nasal congestion and runny nose，and chills in the observation group was shorter than that of the control group，and the differences were statistically significant Significance（Ps<0.05）; the levels of CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group，and CD8+ was lower than the control group，the differences were statistically significant（Ps<0.05）; The levels of IL-8 and TNF-α were lower than those of the control group，and the differences were statistically significant（Ps<0.05）; there was no significant difference in the incidence of adverse reactions between the 2 groups（P>0.05）.Conclusion：Chaiyin Oral Liquid has significant effect in the treatment of children with wind-heat syndrome cold，which is conducive to improving the clinical symptoms of children，improving the body immunity，alleviating the inflammatory reaction，and has good drug safety.

Keywords Chaiyin Oral Liquid; Children with wind-heat syndrome cold; Ribavirin granules;Immune function; Inflammatory factors;Tumor necrosis factor-α; Inflammatory response; Security

中图分类号：R725文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.24.016

小儿风热感冒是儿科临床常见的呼吸系统疾病之一，多发于冬春季节，患儿通常表现出高热、鼻塞流涕、打喷嚏、咳嗽、恶寒等症状。在临床治疗方面，西医认为本病与呼吸道合胞病毒或腺病毒感染有关，或是由溶血性链球菌或肺炎链球菌感染导致，故而多采用抗病毒药物与抗生素治疗[1-2]。……