袁雅峰 赵国娟 陈伟 王涛 耿志勇

摘要 目的：探析采取达利通颗粒联合以阿莫西林为主的三联疗法治疗慢性胃炎的临床效果及对降钙素原（PCT）水平与胃泌素17（G-17）的影响。方法：选取2019年10月至2020年12月马鞍山市中心医院收治的慢性胃炎患者60例作为研究对象，按照随机数字表法随机分为对照组（奥美拉唑+阿莫西林+克拉霉素胶囊三联疗法治疗）和观察组（达利通颗粒联合奥美拉唑+阿莫西林+克拉霉素胶囊三联疗法治疗），每组30例。比较2组患者治疗总有效率、PCT水平、G-17、胃蛋白酶原（PGⅠ、PGⅡ）及不良反应发生率等指标。结果：观察组治疗有效率明显高于对照组（P<0.05）;观察组PCT水平明显低于对照组（P<0.05），G-17水平明显高于对照组（P<0.05）;观察组PGⅠ、PGⅡ等胃蛋白酶原指标明显高于对照组（P<0.05）;与对照组比较，观察组经联合用药治疗后不良反应发生率更低（P<0.05）。结论：慢性胃炎患者采取达立通颗粒联合奥美拉唑+阿莫西林+克拉霉素胶囊三联疗法进行治疗能够有效的改善降钙素原、胃泌素等指标，还可改善血清细胞因子水平，改善胃黏膜病变，降低患者的不良反应，有着安全性高、疗效好等优势，应推广应用。

关键词 慢性胃炎;西药;达立通颗粒;治疗效果;安全性;不良反应;血清细胞因子;胃黏膜病变

Abstract Objective：To explore the clinical effects of Dalitong Granules combined with itopride in the treatment of patients with chronic gastritis and its effect on procalcitonin（PCT） level and gastrin17（G-17）.Methods：A total of 60 patients with chronic gastritis admitted to Ma′anshan Central Hospital from October 2019 to December 2020 were randomly divided into a control group（n=30，Omeprazole+amoxicillin+clarithromycin capsule） and an observation group（Dalitong Granules combined with omeprazole+amoxicillin+clarithromycin capsule），with 30 cases in each group.The total effective rate，PCT level，G-17，pepsinogen（PG Ⅰ，PG Ⅱ） and the incidence of adverse reactions were compared between the 2 groups.Results：The total effective rate of combined treatment group was significantly higher than that of the control group（P<0.05），the PCT level was significantly lower than that of the control group（P<0.05），and the G-17 level was significantly higher than that of the control group（P<0.05） PG Ⅰ and PG Ⅱ in the Observation Group were significantly higher than those in the control group（P<0.05），and the incidence of adverse reactions in the observation group was lower than that in the control group（P<0.05）.Conclusion：Patients with chronic gastritis are treated with Dalitong Granules combined with Omeprazole+amoxicillin+clarithromycin capsule，which can effectively improve the indexes such as procalcitonin and gastrin，improve the level of serum cytokines，improve gastric mucosal lesions and reduce adverse reactions.It has the advantages of high safety and good curative effect，and should be popularized.

Keywords Chronic gastritis; Itopride; Dalitong Granules; Therapeutic effect; Safety; Adverse reactions; Serum cytokines; Gastric mucosal lesions

中圖分类号：R289.5;R573文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.24.014

慢性胃炎在消化系统疾病中发病率较高，其临床表现为腹部胀痛不适、消化不良、嗳气、反酸、烧灼感、胀满等。由于该疾病常反复发作，对患者的健康生活会产生一定的影响[1]。慢性胃炎疾病主要是因为机体感染幽门螺杆菌（Hp）之后胃黏膜出现非特异性炎症变化而造成的疾病，根据慢性胃炎的致病因素，临床主要是通过促进胃动力、保护胃黏膜、抑制酸、根除Hp等药物治疗[2]。……