中国中西医结合学会儿科分会消化学组

摘要 神曲消食口服液具有消食健胃、健脾理气的功效，临床主要用于儿童消化功能紊乱症的治疗，其安全性和有效性得到高度认可。现代药理学研究表明，神曲消食口服液具有促进胃排空及消化液分泌、调节胃肠平滑肌收缩、增加肠道蠕动及小肠吸收、调节平衡肠道菌群、镇痛等作用，可缓解上腹部疼痛或烧灼感、餐后上腹饱胀和早饱感、嗳气、恶心或呕吐等症状。临床研究显示，神曲消食口服液对于厌食症、功能性消化不良、功能性腹痛均具有疗效。结合文献证据和临床专家用药经验，对神曲消食口服液的药理药效研究、临床应用研究及药物安全性进行归纳总结，形成临床应用指导意见，旨在规范临床用药。

关键词 神曲消食口服液;厌食症;功能性消化不良;功能性腹痛

Abstract Shenqu Xiaoshi Oral Liquid has the effects of helping digestion and regulating gastrointestinal function. It is mainly used in the clinical treatment of digestive disorders in children. And its safety and effectiveness have been highly recognized. Modern pharmacological studies have shown that Shenqu xiaoshi Oral Liquid can promote gastric empties and secretion of digestive juice， regulate gastrointestinal smooth muscle contraction， increase intestinal peristalsis and intestinal absorption， regulate and balance intestinal flora， and analgesia. It can relieve epigastric pain or burning， epigastric fullness and early satiety after meal， belching， nausea or vomiting and other symptoms. Clinical studies have shown that the treatment of anorexia， functional dyspepsia and functional abdominal pain by Shenqu Xiaoshi Oral Liquid can significantly improve the clinical symptoms of patients. Based on the literature evidence and the experience of clinical experts in drug use， this paper summarized the pharmacological and pharmacodynamic studies， clinical application studies and drug safety of Shenqu Xiaoshi Oral Liquid， and formed guidance opinions for clinical application， aiming at standardizing clinical drug use.

Keywords Shenqu Xiaoshi Oral Liquid; Anorexia; Functional dyspepsia; Functional abdominal pain

中图分类号：R272文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.22.001

神曲消食口服液，原名为脾胃宁口服液，于2014年作为国家第6类中药批准上市（国药证字号Z20140002），主要成分包括焦神曲、焦山楂、焦麦芽、白芍等，具有助消化、调节胃肠功能的功效，临床主要用于治疗厌食症、功能性消化不良等儿童消化功能紊乱症。中国中医药出版社编写的《实用临床药物学-中成药卷》[1]中，推荐神曲消食口服液用于治疗脾胃虚弱所致小儿食积、儿童消化不良等。

1 指导意见编制方法与过程

本指导意见制定过程中，以“神曲消食口服液”“Shenqu Xiaoshi Oral Liquid”为关键词，在国家知识基础设施数据库（http：//www.cnki.net）、中国学术期刊……