张艳玲

摘要 目的 探讨联合应用吗丁啉与思密达治疗胃食管反流病患者的临床疗效。方法 选取2018年1月—2019年9月我院80例胃食管返流病患者为研究对象。按照性别、年龄组间匹配的原则分为观察组和对照组，每组40例。对照组口服吗丁啉治疗，观察组加用思密达治疗，比较两组的治疗效果。结果 观察组总有效率97.50%，对照组90.00%，差异无统计学意义（P>0.05）;治疗后两组症状与内镜评分均明显降低，但观察组低于对照组，差异有统计学意义（P<0.05）;观察组药物不良反应率2.50%，对照组5.00%，差异无统计学意义（P>0.05）。结论 吗丁啉与思密达联合用药治疗胃食管反流病患者，在改善患者的症状和内镜评分方面，优于单纯使用吗丁啉，效果安全可靠。

关键词 胃食管返流病;吗丁啉;思密达

中图分类号  R57    文献标识码  A    文章编号  1671-0223（2020）18-039-03

OBSERVATION ON THE EFFECT OF DOMPERIDONE COMBINED WITH SMECTA IN THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE Zhang Yanling.Lanzhou Mental Rehabilitation Hospital， Lanzhou 730050，China

Abstract  Objective To explore the clinical efficacy of domperidone combined with Smecta in the treatment of gastroesophageal reflux disease. Methods A total of 80 patients with gastroesophageal reflux disease in our hospital from January 2018 to September 2019 were selected as the research objects.According to the principle of gender and age matching， they were divided into observation group and control group，40 cases in each group. The control group was treated with domperidone，and the observation group was treated with Smecta on the basis of the control group，the therapeutic effects of the two groups were compared.Results The total effective rate of the observation group was 97.50%，while that of the control group was 90.00%.The difference was not statistically significant（P>0.05）. After treatment，the symptoms and endoscopic scores of the two groups were significantly reduced，but the observation group was lower than the control group，the difference was statistically significant（P<0.05）. The adverse drug reaction rate of the observation group was 2.50%，and that of the control group was 5.00%，the difference was not statistically significant（P>0.05）.Conclusion The combination of domperidone and Smecta in the treatment of patients with gastroesophageal reflux disease，in improving the symptoms and endoscopic score of patients， is better than the simple use of Motilium，the effect is safe and reliable.

Key words  Gastroesophageal;Domperidone;Smecta

胃食管反流病屬于近年来临床中高发的消化系统疾病，是指患者胃及十二指肠内容物发生反流后进入到食管内，进一步对食管和组织形成损伤[1]。患者的主要症状表现为胃灼热、咽部不适、异物感、反酸、声音嘶哑、吞咽疼痛以及吞咽困难等，该疾病的发生对于患者的生活质量产生严重影响。目前的研究发现，胃食管反流病的发生是在多因素作用下造成的结果，例如食管抗反酸屏障功能异常、食管粘膜防御功能紊乱以及食管酸清除能力异常等。目前对于胃食管反流病患者主要应用药物治疗来改善患者的临床症状并抑制病情进展，如常用的H2受体阻滞剂、质子泵抑制剂、胃粘膜保护剂以及促胃动力药物等。近年来随着对胃食管反流病的研究不断深入，发现采用联合用药方案治疗能够更好地发挥药物之间的协同作用，从而提升患者的疾病治疗效果。本文……