徐登先 王娟 曾彩云

[摘要] 目的 探究血清胱抑素C（Cys-C）、超敏C反应蛋白（CRP）、同型半胱氨酸（Hcy）联合检测在2型糖尿病肾病中的应用效果。方法 选择该院2016年7月—2019年7月期间收治的40例2型糖尿病并微量白蛋白>200 mg/L的患者、40例2型糖尿病并含有微量白蛋白尿≤200 mg/L患者为研究对象，并分别列为A组、B组，同时选择同期于该院体检的20名健康者作为C组，观察3组的Cys-C、CRP、Hcy含量，并比较A组与B组的Cys-C、CRP、Hcy单独检测阳性率及联合检测的阳性率。结果 A组与B组的Cys-C、CRP、Hcy含量均高于C组，A组的Cys-C、CRP、Hcy含量高于B组，差异有统计学意义（P<0.05）;A组与B组两组的Cys-C、CRP、Hcy联合检测阳性率均高于各指标单独检测的阳性率，且A组的Cys-C、CRP、Hcy联合检测阳性率高于B组，差异有统计学意义（P<0.05）。结论 Cys-C、CRP、Hcy联合检测更有利于2型糖尿病肾病的诊断，并能为临床设计治疗该病的方案提供更准确的依据。

[关键词] Cys-C;CRP;Hcy;2型糖尿病肾病

[中图分类号] R59          [文献标识码] A          [文章编号] 1672-4062（2020）08（a）-0191-03

[Abstract] Objective To explore the effect of combined detection of serum cystatin C （Cys-C）， hypersensitive C-reactive protein （CRP） and homocysteine （Hcy） in type 2 diabetic nephropathy. Methods Forty patients with type 2 diabetes and microalbumin> 200 mg/L， 40 patients with type 2 diabetes and microalbuminuria ≤200 mg/L admitted to the hospital from July 2016 to July 2019 were selected as the research subjects. They were also classified as Group A and Group B respectively. At the same time， 20 healthy people who had undergone medical examinations in the hospital during the same period were selected as Group C. The contents of Cys-C， CRP and Hcy in the three groups were observed， and the Cys-C of Group A and Group B were compared. CRP， Hcy detection positive rate alone and the positive rate of combined detection. Results The contents of Cys-C， CRP and Hcy in Group A and Group B were higher than those in Group C， and the contents of Cys-C， CRP and Hcy in Group A were higher than that in Group B， the difference was statistically significant （P<0.05）; Group A The positive rate of the combined detection of Cys-C， CRP， and Hcy in both groups with Group B was higher than the positive rate of each indicator alone， and the positive rate of the combined detection of Cys-C， CRP， and Hcy in Group A was higher than that of Group B， the difference was statistically significant （P<0.05）. Conclusion The combined detection of Cys-C， CRP and Hcy is more conducive to the diagnosis of type 2 diabetic nephropathy， and can provide a more accurate basis for the clinical design of treatment for the disease.

[Key words] Cys-C; CRP; Hcy; type 2 diabetic nephropathy

2型糖尿病腎病是2型糖尿病的主要并发症之一，该病具体发病机制尚未明确，但该病持续进展，极有可能使患者各器官功能衰竭，并严重威胁患者的生命安全。因此，临床应当尽早对患者确诊并进行治疗，从而尽可能在早期控制疾病，提高患者的生活质量[1]。血清胱抑素C（Cys-C）、超敏C反应蛋白（CRP）、同型半胱氨酸（Hcy）均属于血清标志物之一，由于糖尿病肾病的发生与炎症因子如CRP、Cys-C等有较强的关联性，早期临床诊断2型糖尿病肾病时，常借助检测所得的CRP、Cys-C及Hcy水平进行确诊[2]。然而CRP、Cys-C的水平易受到外界因素影响，单独检测的诊断准确性不够理想，该文旨在探究Cys-C、CRP、Hcy联合检测在2型糖尿病肾病中的应用效果，该文选择2016年7月—2019年7月期间该院收治的80例2型糖尿病肾病及2型糖尿病患者与同期于该院体检的20名健康者进行观察，现报道如下。

1  资料与方法

1.1  一般资料

选择该院收治的40例2型糖尿病并微量白蛋白>200 mg/L的患者、40例2型糖尿病并含有微量白蛋白尿≤200mg/L患者为研究对象，并分别列为A组、B组，同时选择同期于该院体检的20名健康者作为C组。C组男……