薄慧

摘要：目的  观察地特胰岛素注射液在儿童糖尿病患者中的疗效。方法  选取2014年3月～2020年3月我院收治的儿童糖尿病患者72例，按照随机数字表法分为研究组和对照组，各36例。对照组给予常规药物治疗，研究组给予地特胰岛素注射液联合短效胰岛素治疗，比较两组临床疗效、血糖以及BMI指标变化、血清Th1（IL-2、TNF-α）及Th2（IL-4、IL-10）细胞因子水平变化及血糖相关不良事件发生率。结果  研究组治疗总有效率为94.44%，高于对照组的69.44%（P<0.05）;两组FBG、2h PG、HbAlc以及BMI较治疗前改善，且研究组改善水平优于对照组，差异有统计学意义（P<0.05）;两组IL-2、IL-4、IL-10、TNF-α水平较治疗前改善，且研究组的改善水平优于对照组（P<0.05）;研究组血糖相关不良事件发生率为27.78%，低于对照组的61.11%（P<0.05）。结论  地特胰岛素注射液联合短效胰岛素治疗儿童糖尿病疗效确切，可对辅助性Th细胞因子进行有效抑制，促进患者血糖水平改善，且血糖相关不良事件发生率低。

关键词：地特胰岛素注射液;儿童糖尿病;辅助性Th1细胞因子

Abstract：Objective  To observe the efficacy of insulin detemir injection in children with diabetes and its influence on auxiliary Th1 cytokines. Methods  A total of 72 pediatric diabetic patients admitted to our hospital from March 2014 to March 2020 were selected and divided into a study group and a control group according to a random number table， with 36 cases in each group. The control group was given conventional medication， and the study group was given insulin detemir injection combined with short-acting insulin therapy. The clinical efficacy， blood glucose and BMI index changes， serum Th1 and Th2 cytokine levels， and blood glucose-related adverse events were compared between the two groups.Results  The total effective rate of treatment in the study group was 94.44%， which was higher than 69.44% in the control group（P<0.05）; the two groups of FBG， 2h PG， HbAlc and BMI were improved compared to before treatment， and the improvement level of the study group was better in the control group （P<0.05）; the serum Th1 and Th2 cytokine levels of the two groups were improved compared with before treatment， and the improvement of the study group was better than the control group（P<0.05）; The incidence of blood glucose-related adverse events in the group was 27.78%， which was lower than 61.11% in the control group（P<0.05）.Conclusion  Insulin detemir injection combined with short-acting insulin has a definite effect in the treatment of childhood diabetes. It can effectively inhibit auxiliary Th1 cytokines， promote the improvement of blood glucose levels in patients， and has a low incidence of blood glucose-related adverse events.

Key words：Insulin detemir injection;Childhood diabetes;Auxiliary Th1 cytokine

儿童糖尿病大多是因机体胰岛素分泌缺乏而导致的一种内分泌代谢疾病类型，其中碳水化合物、蛋白质以及脂肪代谢异常为主要特征，极易导致患者出现空腹以及餐后高血糖和尿糖等多种疾病[1，2]。儿童作为糖尿病的特殊人群，由于自身缺乏疾病知识，难以对血糖水平进行有效控制，极易引起多种严重并发症，影响儿童的正常生长发育及生活质量[3]。地特胰島素作为一种长效胰岛素类似物，具有一定的可溶性，其药效平缓，作用持续时间较长，不但能有效控制血糖水平，还可减少低血糖等不良反应的发生，减轻对患者身体的损伤，加快机体恢复[4]。本研究结合2014年3月～2020年3月我院72例儿童糖尿病患者的临床资料，探讨地特胰岛素注射液在儿童糖尿病患者中的疗效及对辅助性Th1细胞因子的影响，现报道如下。

1资料与方法

1.1一般资料  选取2014年3月～2020年3月天津市静海区医院儿科收治的儿童糖尿病患者72例，按照随机数字表法分成研究组和对照组，每组36例。……