高瑞婷

[摘要] 目的 研究甘草鋅颗粒对慢性腹泻患儿治疗效果及血锌水平的影响。方法 方便选取该院于2018年4月—2019年1月期间收治的慢性腹泻患儿96例，随机数字表法分为对照组和观察组各48例。对照组行蒙脱石散治疗，观察组于对照组治疗基础上联合甘草锌颗粒治疗。观察对比两组患儿临床疗效、临床症状改善时间以及治疗前后的血锌水平的变化。结果 经14 d治疗后，观察组的治疗总有效率95.83%较对照组77.08%高，差异有统计学意义（χ2=7.207，P=0.007）;观察组发热改善时间（2.01±1.07）d、腹泻改善时间（4.26±1.84）d、住院院时间（5.18±1.26）d均较对照组[（3.65±1.28）、（5.52±1.52）、（7.69±1.62）d]低，差异有统计学意义（t=6.811、3.658、8.473，P=0.000）;观察组血锌水平（67.99±2.47）μmol/L较对照组（60.66±2.88）μmol/L高，差异有统计学意义（t=13.385，P=0.000）。结论 慢性腹泻患儿经甘草锌颗粒治疗可快速缓解患儿发热、大便不正常症状，有效提高患儿体内血锌水平，疗效确切。

[关键词] 慢性腹泻;甘草锌;血锌水平

[中图分类号] R725.7          [文献标识码] A          [文章编号] 1674-0742（2020）06（a）-0103-03

Effect of Glycyrrhizin Zinc Granules on the Treatment Effect and Blood Zinc Level in Children with Chronic Diarrhea

GAO Rui-ting

Department of Pediatrics， Shenxian People's Hospital， Liaocheng， Shandong Province， 252400 China

[Abstract] Objective To study the effect of glycyrrhizin zinc granules on the treatment effect and blood zinc level in children with chronic diarrhea. Methods Ninety-six children with chronic diarrhea treated in the hospital from April 2018 to January 2019 were convenient selected and randomly divided into a control group and an observation group with 48 cases each. The control group was treated with montmorillonite powder， and the observation group was treated with licorice zinc granules based on the treatment of the control group. Observe and compare the clinical efficacy， time to improve clinical symptoms， and changes in blood zinc levels before and after treatment in the two groups of children. Results After 14 d of treatment， the total effective rate of the observation group was 95.83% higher than the control group of 77.08%， the difference was statistically significant （χ2=7.207， P=0.007）; the fever improvement time in the observation group （2.01±1.07）days， diarrhea improvement time （4.26±1.84）d and hospital stay time （5.18±1.26） d were lower than those of the control group [（3.65±1.28）d， （5.52±1.52）d， （7.69±1.62）d]， and the differences were statistically significant（t=6.811， 3.658， 8.473， P=0.000）; the blood zinc level （67.99±2.47）μmol/L in the observation group was higher than the control group （60.66±2.88）μmol/L， and the difference was statistically significant （t=13.385， P=0.000）. Conclusion Children with chronic diarrhea treated with licorice zinc particles can quickly relieve the symptoms of fever and abnormal stool， and effectively increase the blood zinc level in children， and the effect is definite.

[Key words] Chronic diarrhea; Licorice zinc; Blood zinc level

慢性腹泻是较为常见的一种消化系统疾病，多发于免疫力不高、體质较弱的幼儿和老年群体。幼儿发生慢性腹泻的疾病主要临床症状是高烧持续不退、大便稀状、呕吐以及食欲减退等，病程较长患儿会出现严重消瘦、体重下降及腹部凹陷等现象，对患儿生长发育极为不利[1-2]。腹泻有感染性和非感染性腹泻，发作时会伴有呕吐、腹痛等症状，长期慢性腹泻可造成维生素缺乏、贫血以及营养不良，甚至发生休克，需及时治疗。临床上治疗该疾病主要是使用蒙脱石散保护患儿肠黏膜，但是改善慢性腹泻临床症状时间较慢[3]。……