石光锋 王晓霜

[摘要] 目的 分析腹腔鏡直肠癌根治术对老年结直肠癌患者的胃肠功能、胃动素和胃泌素的影响。方法 方便选取2016年3月—2019年3月在该院接受手术治疗的109例结直肠癌患者为研究对象。按照接受手术方法的不同，分为治疗组和对照组，两组分别开展腹腔镜直肠癌根治术和开腹直肠癌根治术，对比两组患者围手术期相关临床指标、术后疼痛评分、并发症发生情况;手术前后帮助患者进行胃动素和胃泌素检测和对比。结果 治疗组手术时长（180.16±23.16）min，切口长度（5.84±2.11）cm、出血量（77.93±29.15）mL、术后排气时间（60.34±5.88）h、进食时间（55.12±3.54）h、住院时间（11.43±3.12）d，对照组手术时长（141.37±28.19）min，切口长度（18.73±4.62）cm、出血量（166.31±43.16）mL、术后排气时间（84.86±15.43）h、进食时间（103.54±9.15）h、住院时间（17.83±5.42）d;两组比较差异有统计学意义（t=7.856、18.793、12.549、11.001、36.559、7.572，P<0.05）。治疗组术后胃动素（325.64±28.53）pg/mL，胃泌素（136.71±15.74）pg/mL，对照组胃动素（279.16±18.34）pg/mL，胃泌素（118.73±18.19）pg/mL，组间数据对比差异有统计学意义（t=121.892、89.791，P<0.05）。结论 老年结直肠癌患者开展腹腔镜直肠癌根治术效果佳、创伤低、并发症少，对胃动素、胃泌素的影响更小，利于老年患者术后胃肠功能及早恢复。

[关键词] 老年结直肠癌;腹腔镜直肠癌根治术;胃肠功能;胃动素;胃泌素

[中图分类号] R573          [文献标识码] A          [文章编号] 1674-0742（2020）06（a）-0058-04

Effects of Laparoscopic Radical Rectal Cancer Surgery on Gastrointestinal Function， Motilin and Gastrin in Elderly Patients with Colorectal Cancer

SHI Guang-feng， WANG Xiao-shuang

Laparoscopic General Surgery， Zibo Central Hospital， Zibo， Shandong Province， 255036 China

[Abstract] Objective To analyze the effects of laparoscopic radical rectal cancer surgery on gastrointestinal function， motilin and gastrin in elderly patients with colorectal cancer. Methods A total of 109 patients with colorectal cancer who underwent surgical treatment in the hospital from March 2016 to March 2019 were included in the study. According to the different surgical methods， they were divided into a treatment group and a control group. The two groups underwent laparoscopic radical rectal cancer surgery and open radical rectal cancer radical surgery. The clinical indicators， postoperative pain scores， and complications incidence of symptoms; help patients to detect and compare motilin and gastrin before and after surgery were compared between the two groups. Results The length of surgery in the treatment group （180.16±23.16）min， the length of the incision （5.84±2.11）cm， the amount of bleeding （77.93±9.15）mL， the postoperative exhaust time （60.34±5.88）h， the time to eat （55.12±3.54）h， and the length of hospitalization （11.43±3.12）d， control group surgery time （141.37±28.19）min， incision length （18.73±4.62）cm， bleeding volume （166.31±43.16）mL， postoperative exhaust time （84.86±15.43）h， eating time （103.54±9.15）h， hospitalization time （17.83±5.42）d; the difference between the two groups was statistically significant （t=7.856， 18.793， 12.549， 11.001， 36.559， 7.572， P<0.05）. Motilin （325.64±28.53）pg/mL， gastrin （136.71±15.74）pg/mL in the treatment group after treatment， motilin （279.16±18.34）pg/mL， and gastrin （118.73±18.19）pg/mL in the control group. There was a statistically significant difference in data comparison between the groups（t=121.892， 89.791， P<0.05）. Conclusion Laparoscopic radical resection of colorectal cancer in elderly patients has good effect， low trauma and fewer complications， and has less effect on motilin and gastrin， which is beneficial to early recovery of gastrointestinal function in elderly patients.

[Key words] Elderly colorectal cancer; Laparoscopic radical rectal cancer surgery; Gastrointestinal function; Motilin; Gastrin

結直肠癌是临床常见的恶性肿瘤类型，近几年发病呈现显著的上升趋势。目前结直肠癌临床手术是主要且相对有效的治疗手段。随着医疗技术的不断提高，腔镜技术在临床治疗中应用的越来越广泛，特别对于老年结直肠癌患者，帮助其选择安全性高、创伤低、利于恢复的术式，是治疗效果和预后的重要保障[1]。传统开腹手术显然已不适合临床和患者的需求，与开腹手术相比，腹腔镜直肠癌根治术视野佳、创伤低，能够缩短术后恢复时间，减少并发症发生率，利于老年患者接受[2-3]。该次研究分析了腹腔镜直肠癌根治术对老年结直肠癌患者的胃肠功能、胃动素和胃泌素的影响，纳入2016年3月—2019年3月在该院接受手术治疗的109例结直肠癌患者为研究对象，现报道如下。……