郎晓玲

[摘要]目的 探讨丙戊酸联合拉莫三嗪治疗癫痫的临床效果。方法 选取2017年1月～2019年6月我院收治的100例癫痫患者作为研究对象，按照随机抽签方法将其分为两组，每组各50例。对照组患者采用丙戊酸治疗方法，研究组患者采用丙戊酸联合拉莫三嗪治疗方法。比较两组患者的临床治疗效果、临床症状情况及不良反应发生情况。结果 研究组患者的临床治疗总有效率高于对照组，差异有统计学意义（P<0.05）;治疗后，研究组患者的发作次数、癫痫样放电次数少于对照组，持续时间短于对照组，累及导联数水平低于对照组，差异有统计学意义（P<0.05）;研究组患者的不良反应总发生率低于对照组，差异有统计学意义（P<0.05）。结论 癫痫患者实施丙戊酸联合拉莫三嗪治疗，临床效果显著，不但可以有效改善患者的相关临床症状，而且安全性高，不良反应发生率低，值得临床应用推广。

[关键词]丙戊酸;拉莫三嗪;癫痫;临床应用价值

[中图分类号] R742.1          [文献标识码] A          [文章编号] 1674-4721（2020）7（a）-0085-03

Clinical effect of Valproic Acid combined with Lamotrigine in the treatment of epilepsy

LANG Xiao-ling

Department of Neurology， Laizhou People′s Hospital， Shandong Province， Laizhou   261400， China

[Abstract] Objective To investigate the clinical effect of Valproic Acid combined with Lamotrigine in the treatment of epilepsy. Methods A total of 100 epilepsy patients admitted in our hospital from January 2017 to June 2019 were selected as subjects， and they were divided into two groups by random lottery， 50 cases in each group. The control group was treated with Valproic Acid， and the study group was treated with Valproic Acid combined with Lamotrigine. The clinical therapeutic effect， clinical symptoms and adverse reactions were compared between the two groups. Results The total effective rate in the study group was higher than that in the control group， and the difference was statistically significant （P<0.05）. After treatment， the number of seizures and epileptiform discharge in the study group were less than those in the control group， the duration was shorter than that in the control group， and the level of lead involvement number was lower than that in the control group， and the differences were statistically significant （P<0.05）. The total incidence of adverse reactions in the study group was lower than that in the control group， and the difference was statistically significant （P<0.05）. Conclusion Patients with epilepsy were treated with Valproic Acid combined with Lamotrigine， it can not only effectively improve the relevant clinical symptoms of patients， but also has high safety and low incidence of adverse reactions. It is worth popularizing in clinical application.

[Key words] Valproic acid; Lamotrigine; Epilepsy; Clinical application value

癲痫为临床常见疾病类型，由于人体大脑神经元突发性异常放电，导致发生大脑功能短暂性障碍，为慢性疾病类型。目前，癫痫是我国常见的第二大神经科疾病类型，发病率仅次于头痛。癫痫疾病的发病元复杂性高，主要包括多方面如脑部疾病、遗传因素等[1-2]。随着临床医学近几年来的高速发展，人们也越来越广泛的认识癫痫，并对癫痫分类[3-4]。目前，如何有效治疗小儿癫痫，已逐渐成为临床医学上的重点关注问题。癫痫疾病的治疗方法主要包括药物治疗、手术治疗、神经调控治疗等方法，其中，主要治疗方式是药物治疗。相关临床研究显示，癫痫患者经药物治疗后，约有70%可以控制其癫痫发作情况[3]。临床近几年的研究发现，通过给予癫痫患者合理联合用药，可以有助于提升其治疗效果[4]。本研究选取我院收治的100例癫痫患者作为研究对象，旨在探讨丙戊酸联合拉莫三嗪治疗癫痫的临床效果，现报道如下。……