何美艳 李远 邹丹婷 刘俊均

[摘要]目的 探讨沙格列汀联合胰岛素治疗在2型糖尿病中的应用效果。方法 回顾性分析我院2017年1月～2019年1月收治的120例2型糖尿病患者的臨床资料，按照用药方式不同分为参照组（n=60）与研究组（n=60）。参照组采用胰岛素治疗，研究组采用胰岛素联合沙格列汀治疗。比较两组的血糖控制情况、治疗效果、血糖达标时间。结果 研究组治疗后的糖化血红蛋白（HbA1c）、空腹血糖（FBG）、餐后2 h血糖（2 h PG）水平低于参照组，差异有统计学意义（P<0.05）。研究组的治疗总有效率为96.67%，高于参照组的83.33%，差异有统计学意义（P<0.05）。研究组的胰岛素用量少于参照组，血糖达标时间短于参照组，差异有统计学意义（P<0.05）。研究组治疗后的体重指数低于参照组，日内血糖平均波动幅度（MAGE）、日内血糖波动次数（NGE）、高血糖曲线下面积（AUC）、日间血糖平均绝对差（MODD）低于参照组，差异有统计学意义（P<0.05）。结论  采取沙格列汀、胰岛素联合用药治疗2型糖尿病患者，能有效控制其血糖水平，临床效果显著，且可以减少胰岛素用量，缩短血糖达标时间，临床价值显著。

[关键词]沙格列汀;胰岛素;2型糖尿病;血糖水平;疗效;胰岛素用量

[中图分类号] R587.1          [文献标识码] A          [文章编号] 1674-4721（2020）7（b）-0073-04

Application effect of combination of Saxagliptin and Insulin in the treatment of type 2 diabetes mellitus

HE Mei-yan   LI Yuan   ZOU Dan-ting   LIU Jun-jun

Department of Endocrinology， Yuedong Hospital， the Third Affiliated Hospital of Sun Yat-Sen University， Guangdong Province， Meizhou   514000， China

[Abstract] Objective To investigate the application effect of combination of Saglitine and Insulin in the treatment of type 2 diabetes mellitus. Methods The clinical data of 120 patients with type 2 diabetes mellitus admitted to our hospital from January 2017 to January 2019 were analyzed retrospectively， The patients were divided into the reference group （n=60） and the study group （n=60） according to different medication methods. The control group was treated with Insulin， while the study group was treated with Insulin combined with Saxagliptin. The blood glucose control， treatment effect and blood glucose reaching standard time were compared between the two groups. Results The levels of HbA1c， FBG and 2 h PG in the study group were lower than those in the control group， the differences were statistically significant （P<0.05）. The total effective rate of the study group was 96.67%， which was higher than 83.33% of the control group， the difference was statistically significant （P<0.05）. The dosage of Insulin in the study group was less than that in the control group， and the time of blood glucose reaching the standard in the study group was shorter than that in the control group， the differences were statistically significant （P<0.05）. After treatment， the body mass index of the study group was lower than that of the control group， and the mean amplitude of glycemic excursion （MAGE）， number of glycemic excursion （NGE）， hyperglycemia of area under curve （AUC） and mean of daily differences （MODD） in the study group were lower than those of the control group， the differences were statistically significant （P<0.05）. Conclusion The combination of Saxagliptin and Insulin can effectively control the blood glucose level of patients with type 2 diabetes mellitus， with significant clinical effect， and can reduce the dosage of insulin， shorten the time of blood glucose reaching the standard， with significant clinical value.

[Key words] Saxagliptin; Insulin; Type 2 diabetes mellitus; Blood glucose level; Efficacy; Insulin dosage

2型糖尿病为常见慢性代谢性疾病，随着人们生活习惯、饮食习惯的改变，近年来糖尿病发病率呈上升趋势[1]。随着2型糖尿病疾病发展，易并发糖尿病足等并发症，进而致使疾病恶化，甚至威胁患者生命健康，因此临床需积极采取治疗以控制2型糖尿病患者的血糖水平。临床多采取胰岛素药物控制2型糖尿病患者的血糖水平，其有较好的临床治疗效果。但相比于单用胰岛素，采取沙格列汀、胰岛素联合用药治疗能够在控制血糖水平的同时减少胰岛素用量，缩短血糖达标时间，减轻患者体重，临床价值更为显著[2]。本研究通过比较单用胰岛素、胰岛素联合沙格列汀治疗2型糖尿病患者的临床效果，旨在探讨沙格列汀联合胰岛素治疗2型糖尿病患者的临床效果，现报道如下。

1资料与方法

1.1一般资料

选取我院2017年1月～2019年1月收治的120例2型糖尿病患者进行回顾性分析，按照用药方式不同分为参照组与研究组，各60例。……