张丽敏

[摘要]目的 探讨长春西汀对慢性脑供血不足患者的临床效果。方法 选取我院2016年5月～2019年5月收治的42例慢性脑供血不足患者作为研究对象，用抽签法随机分为对照组和观察组，各21例，在常规治疗基础上，对照组给予银杏达莫注射液治疗，观察组给予长春西汀治疗，比较两组患者的临床有效率、治疗前后的血流速度及不良反应发生情况。结果 观察组患者的临床总有效率高于对照组，差异有统计学意义（P<0.05）;治疗前两组患者的血流速度比较，差异无统计学意义（P>0.05）;治疗后观察组的血流速度快于对照组，差异有统计学意义（P<0.05）;观察组的不良反应总发生率低于对照组，差异有统计学意义（P<0.05）。结论 长春西汀可提高慢性脑供血不足患者的临床有效率，药物不良反应小，值得推广。

[关键词]长春西汀;慢性脑供血不足;血流速度;安全性

[中图分类号] R743          [文献标识码] A          [文章编号] 1674-4721（2020）7（c）-0076-03

Clinical effect of Vinpocetine in the treatment of chronic cerebral insufficiency

ZHANG Li-min

Department of Neurology， Liaoning Health Industry Group Tiemei Group General Hospital， Liaoning Province， Shenyang   112700， China

[Abstract] Objective To investigate the clinical effect of Vinpocetine on patients with chronic cerebral insufficiency. Methods Forty-two patients with chronic cerebral insufficiency who were treated in our hospital from May 2016 to May 2019 were randomly divided into the control group and the observation group by lottery， each group had 21 patients，on the bases of conventional treatment，the control group accepted Ginkgo Damamo Injection， and the observation group accepted Vnpocetine， and the clinical effectiveness， blood flow rate and adverse reactions before and after treatment were compared between the two groups. Results The total clinical effective rate of the observation group was higher than that of the control group， and the difference was statistically significant（P<0.05）. There was no significant difference in blood flow velocity of patients between the two groups before treatment， the difference was not statistically significant（P>0.05）. The blood flow velocity after treatment was faster than that of the control group， the difference was statistically significant（P<0.05）. The total incidence of adverse reactions was lower than that of the control group， the difference was statistically significant（P<0.05）. Conclusion Vinpocetine can improve the clinical efficiency of patients with chronic cerebral insufficiency， and the adverse drug reactions are small， which is worth promoting.

[Key words] Vinpocetine; Chronic cerebral insufficiency; Blood flow velocity; Safety

腦供血不足属于临床常见的一种神经内科疾病，主要是由于局部脑部血液供应不足而导致脑组织正常能量代谢出现异常、神经递质转变等，最终影响到脑功能的正常运行[1]。脑供血不足可分为急性和慢性两种，后者较为少见，容易被患者忽略，若未能及时发现治疗，随病情发展下去可能引发脑梗死、持久性进展性认知功能障碍及神经功能障碍[2]。慢性脑供血不足患者临床多表现为反复的头晕、头痛症状，并伴有注意力分散、失眠多梦、记忆力减退、烦躁易怒、视力模糊等症状[3]。当前临床治疗慢性脑供血不足的药物包括复方丹参注射液、银杏达莫注射液、长春西汀等，临床疗效各有不同。为进一步探寻更利于提高慢性脑供血不足患者的临床有效率及安全性的疗法，本研究对长春西汀进行重点观察，现将研究内容报道如下。……