冯召岚

[摘要]目的 探讨二甲双胍联合厄贝沙坦治疗糖尿病合并高尿酸血症的效果。方法 选取我院2017年1月～2019年8月接收的80例糖尿病合并高尿酸血症患者作为研究对象，通过随机数字表法分为对照组和实验组，各40例。对照组在常规治疗基础上给予二甲双胍治疗，实验组在对照组基础上联合使用厄贝沙坦治疗。对比两组血糖指标、胰岛素抵抗指数、体重指数变化、血清尿酸水平情况。结果 治疗后，实验组空腹血糖、餐后2 h血糖、糖化血红蛋白水平低于对照组，差异均有统计学意义（P<0.05）;治疗后，实验组胰岛素抵抗指数、体重指数及血清尿酸水平均低于对照组，差异有统计学意义（P<0.05）。结论 二甲双胍联合厄贝沙坦能够降低糖尿病合并高尿酸血症患者体重指数，纠正胰岛素抵抗，调节血糖代谢，降低血清尿酸水平。

[关键词]糖尿病;高尿酸血症;厄贝沙坦;二甲双胍;血糖指标;尿酸水平

[中图分类号] R587          [文献标识码] A          [文章编号] 1674-4721（2020）7（b）-0034-03

Effect of Metformin combined with Irbesartan on clinical symptoms and serum uric acid level in patients with diabetes mellitus complicated with hyperuricemia

FENG Zhao-lan

Department of Endocrinology， the First People′s Hospital of Jiujiang City， Jiangxi Province， Jiujiang   332000， China

[Abstract] Objective To explore the effect of Metformin combined with Irbesartan in the treatment of diabetes with hyperuricemia. Methods A tatal of 80 patients with diabetes and hyperuricemia received in our hospital from January 2017 to August 2019 were selected as the research object and divided into control group and experimental group  by the random number table method， each with 40 cases. The control group accepted Metformin on the basis of conventional treatment， and the experimental group accepted  Irbesartan in combination with the control group. The blood glucose index， insulin resistance index， body mass index changes， and serum uric acid levels were compared between the two groups. Results After treatment， the fasting blood glucose， 2 h postprandial blood glucose， and glycated hemoglobin levels in the experimental group were lower than those in the control group （P<0.05）; after treatment， the insulin resistance index， body mass index， and serum uric acid levels in the experimental group were lower than those in the control group， the differences were statistically significant （P<0.05）. Conclusion Metformin combined with Irbesartan can reduce the body mass index of patients with diabetes and hyperuricemia， correct insulin resistance， regulate blood glucose metabolism， and reduce serum uric acid levels.

[Key words] Diabetes mellitus; Hyperuricemia; Irbesartan; Metformin; Blood sugar index; Uric acid level

糖尿病與高尿酸血症的关系十分密切，二者均属于代谢性疾病，且近年来发病率呈不断上升趋势。相关研究证实，糖尿病患者的血尿酸水平升高与患者肥胖、胰岛素抵抗等密切相关[1]。二甲双胍是临床治疗糖尿病的一线药物，降糖效果明显，还可减少患者肝脏脂肪的堆积，改善糖尿病症状[2]。厄贝沙坦是一种血管紧张素受体拮抗剂，不仅可调节患者血糖，也可控制患者的胰岛素抵抗[3]。目前临床对于这两种药物联合使用治疗糖尿病合并高尿酸血症患者研究并不多见。本研究旨在探讨二甲双胍联合厄贝沙坦治疗对糖尿病合并高尿酸血症患者血糖水平及血清尿酸水平的影响。

1 资料与方法

1.1一般资料

选取我院2017年1月～2019年8月接收的80例糖尿病合并高尿酸血症患者为研究对象，通过随机数字表法分为对照组和实验组，各40例。……