徐明 唐澍 刘琦

[摘要] 目的 探討槐耳颗粒联合紫杉醇和奥沙利铂治疗晚期胃癌的临床效果。 方法 选择2017年1月～2019年1月于湖南省郴州市第一人民医院进行治疗的晚期胃癌患者100例作为研究对象，通过随机数字表法分为观察组（50例）和对照组（50例）。对照组使用紫杉醇和奥沙利铂治疗，观察组在对照组基础上加用槐耳颗粒进行治疗。比较两组患者临床疗效、血清癌胚抗原（CEA）、糖链抗原724（CA724）、糖链抗原199（CA199）、T淋巴细胞亚群、生活质量及不良反应。 结果 观察组总有效率高于对照组，差异有统计学意义（P < 0.05）。治疗后，两组患者CEA、CA724、CA199水平显著低于较治疗前，且观察组患者低于对照组，差异有统计学意义（P < 0.05）。两组患者CD3+、CD4+、CD4+/CD8+水平显著高于治疗前，且观察组高于对照组;两组患者CD8+水平显著低于治疗前，且观察组低于对照组，差异有统计学意义（P < 0.05）。两组患者生活质量显著高于治疗前，且观察组高于对照组，差异有统计学意义（P < 0.05）。两组患者不良反应总发生率比较，差异无统计学意义（P > 0.05）。 结论 晚期胃癌患者使用槐耳颗粒联合紫杉醇和奥沙利铂效果显著，可有效改善患者血清肿瘤标志物水平和生活质量。

[关键词] 槐耳颗粒;紫杉醇;奥沙利铂;晚期胃癌

[中图分类号] R735.2          [文献标识码] A          [文章编号] 1673-7210（2020）07（a）-0097-04

[Abstract] Objective To explore the clinical effect of Huaier Granule combined with Taxol and Oxaliplatin in the treatment of advanced gastric cancer. Methods A total of 100 patients with advanced gastric cancer who were treated in Chenzhou NO.1 People′s Hospital from January 2017 to January 2019 were selected as the research object， while they were divided into observation group （50 cases） and control group （50 cases） by random number table method. The control group was treated with Taxol and Oxaliplatin， and the observation group was treated with Huaier Granules on the basis of the control group. The clinical efficacy， serum carcinoembryonic antigen （CEA）， sugar chain antigen 724 （CA724）， sugar chain antigen 199 （CA199）， T lymphocyte subsets， quality of life and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group， and the difference was statistically significant （P < 0.05）. After treatment， the levels of CEA， CA724， and CA199 in the two groups were significantly lower than those before treatment， while the observation group were lower than those in the control group， and the differences were statistically significant （P < 0.05）. The levels of CD3+， CD4+， CD4+/CD8+ in the two groups were significantly higher than those before treatment， while the observation group were higher than those in the control group; the CD8+ levels of the two groups were significantly lower than those before treatment， while the observation group was lower than the control group， and the differences were statistically significant （P < 0.05）. The quality of life of the two groups were significantly higher than those before treatment， while the observation group was higher than the control group， and the differences were statistically significant （P < 0.05）. The total incidence of adverse reactions between the two groups was not statistically significant （P > 0.05）. Conclusion The use of Huaier Granules combined with Taxol and Oxaliplatin in patients with advanced gastric cancer has a significant effect， which can effectively improve the serum tumor marker levels and quality of life of patients.

[Key words] Huaier Granules; Taxol; Oxaliplatin; Advanced gastric cancer

胃癌是临床常见恶性肿瘤，多发生于50岁以上的中老年人群，随着人们生活水平的提高，胃癌逐渐呈年轻化趋势。据调查显示[1]，超过70%胃癌发生在发展中国家。我国胃癌的发病率是国外的3倍，且多数患者在确诊时已进入晚期，预后较差。目前，晚期胃癌的治疗主要以化疗为主，紫杉醇和奥沙利铂等药物联合的化疗方案是用于治疗晚期胃癌的常用方法。紫杉醇是从紫杉树的树皮中提取合成的一种药物，能抑制肿瘤细胞的分裂[2]。奥沙利铂具有强大的抗肿瘤细胞活性作用，耐药性相对较低，且不良反应相对较小。但化疗方案对患者病情较难缓解，导致晚期胃癌患者的治疗效果不佳[3]。……