卢怡 蒯仂 茹意 罗月 许逊哲 徐蓉 李欣 赵克勤 李斌

摘要  目的：為依据阴阳学说开展皮肤病中医辨证论治提供一种决策支持用数学模型，以期促进中医皮肤病辨证论治理论的现代化。方法：把集对分析理论中的八元联系数对应于太阳经、阳明经、少阳经、太阴经、少阴经、厥阴经以及任督二脉，根据“阴阳平衡”机体正常运行原理，设定八元联系数各联系分量值各在1/8，建立集对分析的阴阳平衡方程。结果：从临床案例发现，患者皮疹疾患主要归于足太阳经和足阳明经，应用阴阳平衡方程得出失衡还处在“量变”的“+++”阶段，若辨证用药得当，可在短期内获得显著效果，和实际情况一致。结论：集对分析的阴阳平衡方程可作为辨证论治皮肤病的辅助模型，其他疾病的辨证论治过程中亦可借鉴应用该方程。

关键词  阴阳理论;皮肤病;辨证论治;六经学说;数学模型;阴阳平衡方程;集对分析;联系数

Preliminary Study on the Application of Yin and Yang Balance Equation Based on Set Pair Analysis in the Diagnosis and Treatment of Skin Diseases

LU Yi1，KUAI Le1，RU Yi1，LUO Yue1，XU Xunzhe1，XU Rong1，LI Xin1，ZHAO Keqin2，LI Bin1

（1 Yueyang Integrated Chinese and Western Medicine Hospital Affiliated to Shanghai University of TCM，Shanghai 200437，China; 2 Zhuji Institute of Contact Mathematics，Zhuji 311811，China）

Abstract Objective： To provide a mathematical model for decision support based on yin and yang theory，in order to promote the modernization of syndrome differentiation theory for TCM dermatopathy. Methods： First，as for the eight-element connection number in the set pair analysis theory corresponded to the Taiyang meridian，Yangming meridians，Shaoyang meridians，Taiyin meridians，Shaoyin meridians，Jueyin meridians and RenDu two meridians，according to the “Yin and Yang Balance” body normal operating principal，the value of each contact component of the eight-element contact number was about 1/8.When the patient was sick，the value of some contact components changes.The medication of syndrome differentiation and treatment was to restore these small or significant changes to normal physiological state; for this reason，the octal connection number was written as the equation of the left yin and right yang，called the yin and yang equilibrium equation based on set pair analysis.Combined the medical case in the literature，the clinical application of the equation was explained. Results： The solution to the yin-yang balance equation was appropriate to the yin-yang theory-based dermatological diagnosis and treatment method summarized in a literature.It was an intuitive mathematical model for decision-making support for TCM syndrome differentiation of dermatology. Conclusion： The yin and yang balance equation based on set pair analysis can be applied in the clinical diagnosis and treatment of skin diseases in TCM，and can be used as a decision support model for syndrome differentiation and treatment of skin diseases.The TCM clinical practice of other diseases can also learn from this equation.

Keywords  Yin and yang theory; Skin disease; Syndrome differentiation; The six classics; Mathematical model; Yin and yang balance equation; Set pair analysis; Number of contacts

中图分类号：R241;R242 文献标识码：A  doi： 10.3969/j.issn.1673-7202.2020.14.032

阴阳理论是中医辨证论治的一个基础性理论，历代中医医家在辨证论治各种疾病时创立的各种学说，说到底都是以阴阳理论为基础[1]。另一方面，从现代医学角度看，中医临床实践中面临的大量病患病例，离不开基于数学的统计分析和建立相应的数学模型[2-4]，以提高抽象思辨能力和辨证论治水平，最终提高临床疗效。数据挖掘涉及的学科领域和方法众多，基于此思考，我们在皮肤病中医用药选优研究中采用集对分析理论和方法取得若干成果的基础上，提出基于集对分析的阴阳平衡方程，结合我们的临床经验和相关文献，阐述该模型的创新思路和临床应用。……