李芳 岳雯 黄秀锦 粱湘钰 高金鸟

摘要  目的：觀察针刺配合艾灸治疗肾阴虚型卵巢储备功能不足（DOR）的影响。方法：选取2017年4月至2019年8月海南医学院第一附属医院收治的DOR患者65例作为研究对象，按照随机数字表法随机分为针灸组（ n =17）、中药组（ n =21）和西药组（ n =20），3组均治疗3个月经周期后，观察临床疗效、中医症状积分，血清卵泡刺激素（FSH）、雌二醇（E2）、FSH/LH及抗缪勒管激素（AMH）水平。结果：在改善中医症状积分、血清FSH、FSH/LH方面，针灸组及中药组均优于西药组;E23组治疗前后有统计学意义，但组间比较无明显差异;AMH3组治疗前后比较差异无统计学意义，组间比较无统计学意义。3组中医症候疗效3组治疗前后差异有统计学意义，针灸组和中药组优于西药组。结论：针灸和中药一样能改善卵巢功能，改善临床症状，也是治疗卵巢储备功能不足的好的治疗手段。

关键词  卵巢储备功能不足;肾阴虚;电针;艾灸;卵巢功能;血清卵泡刺激素;雌二醇;抗缪勒管激素

Acupuncture Combined with Moxibustion for Insufficient Ovarian Reserve Function of Kidney Yin Deficiency

LI Fang， YUE Wen， HUANG Xiujin， LIANG Xiangyu， GAO Jinniao

（Department of Gynaecology， the First Affiliated Hospital of Hainan Medical College， Haikou 571800， China）

Abstract Objective： To observe the effects and evaluation of acupuncture combined with moxibustion in the treatment of kidney yin deficiency type ovary reserve function（DOR）.  Methods： A total of 65 patients admitted to the First Affiliated Hospital of Hainan Medical College from April 2017 to August 2019 with DOR were randomly divided into 3 groups according to the random number table method， 17 in the treatment group， 21 in the Chinese medicine group， and 20 in the Western medicine group. After treatment for 3 months， the 3 groups were observed for clinical efficacy， traditional Chinese medicine symptom score， serum follicle stimulating hormone（FSH）， estradiol（E2）， FSH/LH， and anti-Muller′s（AMH）levels. Results： In terms of improving traditional Chinese medicine symptom scores， serum FSH， FSH/LH， the acupuncture group and the traditional Chinese medicine group were superior to the Western medicine group; the E23 groups had statistical significance before and after treatment， but there was no significant difference between the groups; the AMH3 groups had no statistical significance before and after treatment， no statistical significance between the groups. The therapeutic effects of the 3 groups of traditional Chinese medicine symptoms were statistically significant before and after treatment. The acupuncture group and the traditional Chinese medicine group were superior to the Western medicine group.  Conclusion： Acupuncture， like traditional Chinese medicine， can improve ovarian function and improve clinical symptoms， and it is also a good treatment for ovarian reserve deficiency.

Keywords  Insufficient ovarian reserve; Kidney yin deficiency; Electroacupuncture; Moxibustion; Ovarian function; Serum follicle stimulating hormone; Estradiol; Anti-müllerian

中图分类号：R245;R256.5 文献标识码：A  doi： 10.3969/j.issn.1673-7202.2020.14.030

卵巢储备功能不足（Insufficient Ovarian Reserve，DOR）是指卵巢产生卵子数量不足或质量下降，从而生殖能力下降和生殖内分泌功能紊乱[1-2]。对女性患者的身体健康和心理健康造成严重影响。因此如何改善卵巢储备功能，缓解症状，提高受孕率，具有重要意义。目前，现代医学激素替代治疗存在很多问题[3-4]。我们采用电针配合艾灸治疗肾阴虚DOR患者。现报道如下。

1 资料与方法

1.1 一般资料

选取2017年4月至2019年8月海南医学院第一附属医院收治的DOR患者65例作为研究对象，按照随机数字表法随机分为针灸组、中药组和西药组。……