戴义娟 王涛 初晨

摘要  目的：探析腸胃康颗粒联合质子泵抑制剂用于感染性腹泻患者的临床效果。方法：选取2017年1月至2020年1月马鞍山市中心医院收治的感染性腹泻患者64例作为研究对象，按照随机数字表法分为对照组与观察组，每组32例。对照组研究对象用抗生素（头孢哌酮钠-他唑巴坦钠）进行治疗，观察组研究对象除抗生素外，用枫蓼肠胃康颗粒联合质子泵抑制剂（泮托拉唑）进行治疗，比较治疗有效率、不良反应发生率、症状改善时间、C反应蛋白（CRP）与白细胞计数等指标。结果：与对照组比较，观察组的治疗有效率明显较高，差异有统计学意义（ P <0.05）;观察组不良反应发生率明显低于对照组，差异有统计学意义（ P <0.05）;观察组的脱水纠正时间、退热时间、止泻时间等明显短于对照组，差异有统计学意义（ P <0.05）;与对照组比较，观察组用药后CRP与白细胞计数明显较低，差异有统计学意义（ P <0.05）。结论：感染性腹泻采取质子泵抑制剂联合枫蓼肠胃康颗粒进行治疗能够获得较为理想的效果，能提升治疗效果，降低不良反应发生率，能缩短疾病康复时间。

关键词  感染性腹泻;质子泵抑制剂;泮托拉唑;头孢哌酮钠-他唑巴坦钠;枫蓼肠胃康颗粒;治疗效果;不良反应;治疗有效率

Observation on the Effects of Changweikang Granule Combined with Proton Pump Inhibitor on Infectious Diarrhea

DAI Yijuan， WANG Tao， CHU Chen

（Gastroenterology Department， Maanshan Central Hospital， Maanshan 243000， China）

Abstract Objective： To explore the effects of Changweikang Granule combined with proton pump inhibitor for infectious diarrhea.  Methods： A total of 64 patients with infectious diarrhea admitted to Maanshan Central Hospital from January 2017 to January 2020 were selected as the research objects and were divided into a control group（ n =32）and an experimental group（ n =32）according to the random number table. The control group were treated with antibiotics（cephalosporin sodium-tazobactam sodium）. And the experimental group were treated with Fengliao Changweikang Granules combined with proton pump inhibitors（pantoprazole）. Indicators such as efficiency， incidence of adverse reactions， symptom improvement time， CRP and white blood cell count were compared.  Results： Compared with the control group， the total effective rate of treatment in the experimental group was significantly higher（ P <0.05）; the incidence of adverse reactions in the experimental group was significantly lower than the control group（ P <0.05）; the dehydration correction time， antipyretic time and antidiarrheal time in the experimental group were significantly shorter than that of the control group（ P <0.05）; compared with the control group， the CRP and white blood cell count of the experimental group were significantly lower（ P <0.05）.  Conclusion： Treatment of infectious diarrhea with proton pump inhibitor combined with Fengliao Changweikang Granules can obtain a relatively ideal effects， improve the treatment effects， reduce the incidence of adverse reactions， and shorten the recovery time of the disease.

Keywords  Infectious diarrhea; Proton pump inhibitor; Pantoprazole; Cefoperazone sodium-tazobactam sodium; Fenglang Changweikang Granules; Therapeutic effects; Adverse reactions; Total effective rate

中图分类号：R289.5;R256.3 文献标识码：A  doi： 10.3969/j.issn.1673-7202.2020.14.021

消化系统常见疾病中感染性腹泻具有极高的发病率，具有流行广泛、发病率高等基本特征，对人类的身体健康产生严重的危害[1]。感染性腹泻主要是因为寄生虫、细菌、病毒等病原体造成的疾病，其临床表现以腹泻为主，具有一定的传染性。患者在发病后会逐渐增加大便的次数，且大便性状出现异常的症状，不但会使患者的工作以及日常生活受到影响，还会导致生命质量降低。目前，感染性腹泻的治疗主要是以抗生素治疗为主，能够促使腹泻症状得到明显缓解，对感染有所控制，但极易造成肠道菌群失调、胃肠道反應等不良反应[2]。因此，应该及时寻求一种辅助治疗措施，降低感染性腹泻的危害性。……