李慧 艾平

[摘要]目的：分析复方甘草酸苷联合氢醌乳膏治疗面部黄褐斑的疗效。方法：选取2017年1月-2018年12月于笔者医院皮肤科就诊的142例面部黄褐斑患者为研究对象，并根据患者的治疗方案进行分组，观察组：71例，采用复方甘草酸苷联合氢醌乳膏进行治疗;对照组：71例，采用氢醌乳膏进行治疗。比较两组患者治疗前后皮肤屏障生理功能指标以及治疗前后皮损面积、颜色。结果：观察组患者治疗有效率明显高于对照组，差异具有统计学意义（P<0.05）。比较两组患者治疗前后皮肤屏障生理功能指标，差异具有统计学意义（P<0.05），观察组患者治疗后角质层含水量明显高于对照组，差异具有统计学意义（P<0.05）;观察组患者治疗后经皮失水值以及皮肤黑色素明显低于对照组，差异具有统计学意义（P<0.05）。治疗后，观察组黄褐斑面积明显低于对照组，差异具有统计学意义（P<0.05），观察组黄褐斑颜色明显低于对照组，差异具有统计学意义（P<0.05）。结论：复方甘草酸苷联合氢醌乳膏治疗面部黄褐斑安全、有效，并能够通过调节患者血清性激素的表达水平改善其疗效。

[关键词]甘草酸苷;氢醌乳膏;面部黄褐斑;血清性激素;皮肤黑色素

Abstract：  Objective To analyze the therapeutic effect of compound glycyrrhizin combined with hydroquinone cream on facial chloasma.  Methods  A total of 142 patients with facial melasma admitted to our department of skin and beauty from January 2017 to December 2018 were divided into observation group （n=71， compound glycyrrhizin combined with hydroquinone cream） and control group （n=71， hydroquinone cream） according to the treatment plan. Skin barrier physiological function index and area and color before and after treatment were compared between the two groups. Results The effective rate of treatment in the observation group was significantly higher than that in the control group （P<0.05）.The differences of skin barrier physiological function indexes before and after treatment between the two groups were statistically significant （P<0.05）. The water content of the stratum corneum in the observation group was significantly higher than that in the control group after treatment （P<0.05）. The transepidermal water loss and skin melanin were significantly lower than the control group after treatment （P<0.05）. There was no significant difference in the area of chloasma between the two groups before treatment （P>0.05）. The area of chloasma in the observation group was significantly lower than that in the control group （P<0.05）.There was no significant difference in the color of chloasma between the two groups before treatment （P>0.05）.After treatment， the color of chloasma in the observation group was significantly lower than that in the control group （P<0.05）. Conclusion Compound glycyrrhizin combined with hydroquinone cream is safe and effective on the treatment of facial chloasma， and can improve the therapeutic effect by regulating the expression level of serum sex hormones.

Key words： glycyrrhizin; hydroquinone cream; facial chloasma; serum sex hormone; skin melanin

黃褐斑是临床上常见的皮肤病之一，主要临床表现为患者面部出现对称性的色素斑片，多见于中青年女性[1-2]。因其发病机制较为复杂，与多种因素相关，且尚不明确，故治疗方案较多，其中包括中西药口服、外用、激光、光子以及果酸等治疗方案，均具有一定疗效，但不明显[3-5]。复方甘草苷酸在既往研究中多用于治疗慢性肝病，但对湿疹、皮炎以及荨麻疹具有一定疗效，氢醌乳膏为皮肤退色剂，是针对黄褐斑、雀斑以及老年斑等皮肤损伤留下色素沉着等疾病的治疗药物，但临床上探讨复方甘草酸苷联合氢醌乳膏治疗面部黄褐斑的疗效尚缺[6-8]。故本研究选取笔者医院皮肤美容科近年来就诊的142例面部黄褐斑患者的临床资料进行回顾性分析，旨在研究复方甘草酸苷联合氢醌乳膏治疗面部黄褐斑的疗效，现将结果报道如下。

1  资料和方法

1.1 一般资料：选取2017年1月-2018年12月于笔者医院皮肤美容科就诊的142例女性面部黄褐斑患者为研究对象。……