李小龙

【摘要】 目的：探究對痉挛发作类癫痫老年患者给予丙戊酸钠缓释片结合生酮饮食治疗的临床效果。方法：选取笔者所在医院2018年4月-2019年5月收治的老年痉挛发作类癫痫患者46例，随机均分为观察组和对照组，各23例。对照组给予常规治疗方案;观察组采取丙戊酸钠缓释片结合生酮饮食治疗，记录对比两组患者的治疗效果。结果：观察组总有效率（95.65%）明显高于对照组（78.26%），差异有统计学意义（P<0.05）;观察组治疗1、2个月的认知功能评分显著高于对照组，差异均有统计学意义（P<0.05）;观察组治疗1、2个月的癫痫发作频率低于对照组，持续时间明显短于对照组，差异均有统计学意义（P<0.05）。结论：丙戊酸钠缓释片结合生酮饮食治疗法对老年痉挛发作类癫痫有显著临床效果，可有效抑制患者病情发展，有较高的临床应用价值。

【关键词】 丙戊酸钠缓释片 生酮饮食 老年痉挛发作类癫痫

doi：10.14033/j.cnki.cfmr.2020.10.058 文献标识码 B 文章编号 1674-6805（2020）10-0-03

Clinical Efficacy of Sodium Valproate Sustained Release Tablets Combined with Ketogenic Diet in the Treatment of Senile Spasmodic Epilepsy/LI Xiaolong. //Chinese and Foreign Medical Research， 2020， 18（10）： -140

[Abstract] Objective： To explore the clinical effect of Sodium Valproate Sustained Release Tablets combined with ketogenic diet in the elderly patients with spasmodic epilepsy. Method： A total of 46 elderly patients with spasmodic epilepsy admitted to our hospital from April 2018 to May 2019 were randomly divided into observation group and control group， with 23 cases in each group. The control group was given conventional treatment. The observation group was given Sodium Valproate Sustained Release Tablets combined with ketogenic diet. And the treatment effect of the two groups was recorded and compared. Result： The total effective rate of the observation group （95.65%） was significantly higher than that of the control group （78.26%）， the difference was statistically significant （P<0.05）. The cognitive function scores of the observation group for one and two months were significantly higher than that of the control group， the differences were statistically significant （P<0.05）. The seizure frequency of the observation group for one and two months was lower than that of the control group， and the duration was significantly lower than that of the control group， the differences were statistically significant （P<0.05）. Conclusion： The combination of Sodium Valproate Sustained Release Tablets and ketogenic diet has significant clinical effect in the treatment of senile spasmodic epilepsy， which can effectively inhibit the development of patients condition and has high clinical application value.

[Key words] Sodium Valproate Sustained Release Tablets Ketogenic diet Senile spasmodic epilepsy

First-authors address： Xishui Hospital Affiliated to Hubei University of Science and Technology， Xishui 438299， China

癫痫俗称“羊癫疯”或“羊角疯”，属大脑神经性异常放电所致短暂性大脑功能障碍疾病[1]。痉挛发作类癫痫是以痉挛为主药表现形式的常见癫痫症状，其具有发病突然发、病率高、病情复杂等特性，严重影响了患者生命安全和健康[2]。目前传统治疗方法以托吡酯片为主的药物保守治疗法，但所取得的效果欠佳[3]。近年来，许多学者发现丙戊酸钠缓释片可作为改善癫痫病情的药物，并有研究结果表明，其临床疗效尚佳[4]。本研究以丙戊酸钠缓释片结合生酮饮食对老年痉挛发作类癫痫进行治疗，并分析临床效果，現报道如下。

1 资料与方法

1.1 一般资料

选取2018年4月-2019年5月于笔者所在医院进行治疗的46例老年痉挛发作类癫痫患者，纳入标准：（1）临床诊断符合相关癫痫疾病诊断标准;（2）属痉挛发作类癫痫患者;排除标准：（1）药物不耐受患者;（2）重要器官严重并发症、有神经系统疾病史患者;（3）尿素循环功能障碍者。……