戴莹 宋砚斌

[摘要]目的：探讨富血小板纤维蛋白（Platelet-rich fibrin，PRF）对牙龈缺损软组织修复及再生能力的影响。方法：按照随机数字表法将2019年1月-12月笔者医院收治的80例牙龈软组织缺损患者分为观察组与对照组，每组40例。两组分别在软组织缺损位置植入PRF膜与海奥口腔修复膜，比较两组的愈合时间及术后第5天、第10天的愈合率及创面分泌物中胶原酶-1水平;术后第5天，对两组患者的创面疼痛、肿胀及出血进行评分。结果：观察组的愈合时间明显短于对照组（P<0.05）;观察组在术后第5天、第10天的愈合率均明显高于对照组（P<0.05）;观察组术后第5天、第10天的创面分泌物中胶原酶-1水平均明显高于对照组（P<0.05）;观察组术后第5天的创面疼痛、肿胀及出血评分均明显低于对照组（P<0.05）。结论：PRF能够诱导牙龈缺损软组织的修复及再生。

[关键词]牙龈软组织缺损;富血小板纤维蛋白;修复;再生;胶原酶-1

[中图分类号]R781.5    [文献标志码]A    [文章编号]1008-6455（2020）12-0109-03

Effects of Platelet-rich Fibrin on Soft Tissue Repair and Regeneration of Periodontal Defects

DAI Ying，SONG Yan-bin

（Department of Stomatology， the First People's Hospital of Huai'an City， Huai'an 223300，Jiangsu，China）

Abstract： Objective  To discuss the effects of platelet-rich fibrin（PRF） on soft tissue repair and regeneration of periodontal defects. Methods According to the random number method， 80 patients with periodontal tissue defects who were divided into the observation group and the control group in our hospital from January to December 2019， with 40 patients in each group. PRF membrane and Haio oral repair membrane was implanted in the site of soft tissue defect in the observation group and the control group， respectively. The healing time was compared between the two groups. Thealing rate and collagenase-1 level of wound secretions were compared between the two groups at the 5th and 10th day after surgery. The wound pain， swelling and bleeding was scored in two groups at the 5th day after surgery. Results The healing time in the observation group was significantly shorter than that in the control group（P<0.05）. At the 5th and 10th day after surgery， the healing rate in the observation group was significantly higher than that in the control group（P<0.05）， the healing rate and collagenase-1 level of wound secretions in the observation group was significantly higher than that in the control group（P<0.05）. At the 5th day after surgery， the wound pain， swelling and bleeding scores in he observation group were significantly lower than that in the control group（P<0.05）. Conclusion  PRF could induce the soft tissue repair and regeneration of periodontal defects.

Key words：periodontal tissue defects; platelet-rich fibrin; repair; regeneration; collagenase-1

牙齦软组织缺损常由外伤、肿瘤及感染等因素导致，寻找一种能够使牙龈软组织黏膜的功能与形态接近理想状态的修复方法是口腔临床实践中研究的热点。邻近黏膜转移是一种比较理想的修复方式，但是供区及种植范围有限，缝合难度较大，且可能对术区周围组织产生影响[1]，不利于预后。随着生物材料学的不断发展，各种新型组织修复材料逐渐得到应用。富血小板纤维蛋白（Platelet-rich fibrin，PRF）是一种自体的白细胞和富血小板纤维生物材料，往往制备成膜状，用于创面的修复[2]。本研究旨在探讨PRF对牙龈缺损软组织修复及再生能力的影响，以期为临床治疗方案的制定提供参考。

1  资料和方法

1.1 一般资料：选取2019年1月-12月笔者医院收治的80例牙龈软组织缺损患者为研究对象。按照随机数字表法将患者分为观察组和对照组，每组40例。……