肖萍

【摘 要】目的：探究地诺前列酮、米索前列醇、缩宫素用于促宫颈成熟、引产效果。方法：以宫颈不成熟足月产妇150例（时间所选为2018年1月-2018年12月），作为此次研究对象，将其简单化分组，A组实施地诺前列酮（欣普贝生）干预，B组实施米索前列醇干预，C组实施缩宫素干预，对比3组产妇促宫颈成熟、引产的效果。结果：A组与B组用药至临产时间均明显短于C组，P<0.05;A组与B组用药至临产时间相比，无统计学意义（P>0.05）;3组产程时间、产后出血量相比，均无统计学意义（P>0.05）;A组与B组阴道分娩率均明显高于C组，P<0.05;A组与B组阴道分娩率相比，无统计学意义（P>0.05）;3组不良反应发生率相比，无统计学意义（P>0.05）。结论：宫颈不成熟足月产妇接受地诺前列酮、米索前列醇、缩宫素干预，均可获得一定的效果，其中地诺前列酮的应用，安全性、有效性、便利性更优。

【关键词】地诺前列酮;促宫颈成熟;引产;米索前列醇;缩宫素

Abstract：Objective To investigate the effects of dinoprostone， misoprostol and oxytocin in promoting cervical ripening and induction of labor.Methods 150 cases of cervix immature full-term maternal women （selected from January 20 to December 2018） were selected as the subjects of this study.Group A was treated with dinoprostone （Hempbeson）.Intervention， group B was treated with misoprostol， and group C was treated with oxytocin， comparing the effects of three groups of women to promote cervical ripening and induction of labor.Results The doses from group A to group B were significantly shorter than those in group C， P<0.05.There was no significant difference between group A and group B compared with labor time （P>0.05）.Three groups of labor time and postpartum hemorrhage There was no significant difference in the amount （P>0.05）.The vaginal delivery rates of group A and group B were significantly higher than those of group C， P<0.05.There was no statistically significant difference between group A and group B.P>0.05）; There was no statistically significant difference in the incidence of adverse reactions in the three groups （P>0.05）.Conclusions Cervical immature full-term women receiving dinoprostone， misoprostol and oxytocin can achieve certain effects.The application of dinoprostone is safe， effective and convenient.

Key words： dinoprostone; cervical ripening; induced labor; misoprostol; oxytocin

【中图分类号】R719【文献标识码】B【文章编号】1005-0019（2019）17-0-01

在妊娠晚期，若产妇存在胎膜早破、妊娠期高血壓、过期妊娠、妊娠糖尿病等情况，则继续妊娠会对胎儿以及产妇造成一定的风险，因此，应及时为其实施引产干预，来对妊娠终止[1]。剖宫产在我国有着较高的发生率，研究显示产程停滞、胎儿窘迫、社会因素等是导致剖宫产率升高的主要原因，同时，引产失败也是剖宫产的一种主要原因。因此，在为产妇实施引产的过程中，应选择有效性、安全性高的药物，目前临床引产常用的药物为硫酸脱氢表雄酮、吸湿扩张物、米非司酮、雌激素类药物、蓖麻油、催产素、前列腺素类药物等，其中最为有效的促宫颈成熟药物为缩宫素、前列腺类药物，不同的药物，其应用的安全性和有效性，可能具有一定的差异性。本研究主……