阿托伐他汀钙联合硝苯地平、盐酸普萘洛尔治疗冠心病的临床效果
2019-10-21张素云耿继光
张素云 耿继光

摘要:目的 探討阿托伐他汀钙片联合心血管药物治疗冠心病的临床效果。方法 选取我院2018年1月~2月收治的70例冠心病患者,随机分为研究组和对照组,各35例。两组患者均给予常规基础治疗,对照组在此基础上给予辛伐他汀钙片,研究组采用阿托伐他汀片治疗,比较两组患者三酰甘油(TG)、血总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平及治疗效果。结果 对照组TC、TG、LDL-C分别为(3.13±0.29)mmol/L、(5.74±0.32)mmol/L、(3.67±0.25)mmol/L,高于研究组的(2.05±0.32)mmol/L、(4.98±0.36)mmol/L、(3.01±0.22)mmol/L,差异有统计学意义(P<0.05);对照组HDL-C水平低于研究组[(1.08±0.05)mmol/L vs (1.63±0.07)mmol/L],差异有统计学意义(P<0.05);研究组治疗总有效率为94.29%,高于对照组的80.00%,差异有统计学意义(P<0.05)。结论 阿托他汀钙片治疗冠心病临床效果较好,有助于调理患者脂代谢水平,延缓和控制疾病发展,改善患者血脂水平。
关键词:阿托伐他汀钙片;辛伐他汀;冠心病
Abstract:Objective To investigate the clinical effect of atorvastatin calcium tablets combined with cardiovascular drugs for coronary heart disease. Methods 70 patients with coronary heart disease admitted to our hospital from January to February 2018 were randomly divided into study group and control group, 35 cases each. The two groups were given routine basic treatment. The control group was given simvastatin calcium tablets. The study group was treated with atorvastatin tablets. The two groups were compared with triglyceride (TG) and total cholesterol (TC). High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) levels and therapeutic effects.Results The TC, TG and LDL-C of the control group were (3.13±0.29) mmol/L, (5.74±0.32) mmol/L, and (3.67±0.25) mmol/L, respectively, which was higher than that of the study group (2.05±0.32) mmol/ L, (4.98±0.36) mmol/L,(3.01±0.22) mmol/L, the difference was statistically significant (P<0.05); the HDL-C level of the control group was lower than the study group [(1.08±0.05) mmol/L Vs (1.63±0.07) mmol/L], the difference was statistically significant (P<0.05).The total effective rate of the study group was 94.29%, which was higher than that of the control group 80.00%,the difference was statistically significant(P<0.05).Conclusion Atorvastatin calcium tablets have a good clinical effect in the treatment of coronary heart disease, which helps to regulate the level of lipid metabolism, delay and control the development of disease, and improve the blood lipid level of patients.
Key words:Atorvastatin calcium tablets;Simvastatin;Coronary heart disease
冠心病(coronary heart disease,CHD)作为心血管系统的常见疾病,该病导致患者冠状动脉结构和功能异常,常诱发心力衰竭、心律失常等[1],严重危害人们的健康和生命安全。目前,随着人口老龄化的发展,冠心病的发病率逐年升高,有研究表明冠心病与高脂血症密不可分,临床治疗冠心病首先需对高脂血症进行有效控制[2-4]。临床上治疗冠心病的常用心血管药物包括硝酸酯类、β受体阻滞剂、钙拮抗剂等,阿托伐他汀钙片是治疗高血脂的药物,具有抗炎、抗氧化以及改善血管内皮、脂代谢的功能,临床反馈的效果较好[5]。为研究阿托他汀钙片联合心血管药物治疗冠心病的效果,笔者选取我院院2018年1月~12月收治的70例冠心病患者,观察阿托伐他汀钙片联合心血管药物的应用效果,现报告如下。
1资料与方法
1.1一般资料 选取阜南县中医院2018年1月~12月收治的70例冠心病患者,表现为心绞痛、胸闷、胸痛、乏力等,其中男32例,女38例,年龄32~90岁,平均年龄(65.34±4.87)岁。……
