吴晓侠

[摘要] 目的 探讨妊娠期糖尿病并发先兆早产的患者采用羟苄羟麻黄碱治疗总有效率及预后。方法 2018年1月—2019年1月间选择该院妇产科妊娠期糖尿病患者80例，随机分组，对照组40例采用硫酸镁治疗，观察组40例采用羟苄羟麻黄碱治疗。 结果 观察组先兆早产病例总有效率、保胎成功率均高于对照组（P<0.05）;观察组累积用药时间、阴道出血时间均少于对照组，延长孕期时间长于对照组，新生儿体重量高于对照组（P<0.05）;观察组不良反应率低于对照组（P<0.05）。 结论 妊娠期糖尿病合并先兆早产的患者，应用羟苄羟麻黄碱治疗，可提高总有效率及保胎成功率，缩短用药及阴道流血时间，延长孕期，改善新生儿体重量，且具较高安全性。

[关键词] 妊娠期糖尿病;先兆早产;羟苄羟麻黄碱;总有效率;保胎率

[中图分类号] R587.1          [文獻标识码] A          [文章编号] 1672-4062（2019）06（a）-0079-02

[Abstract] Objective To investigate the total effective rate and prognosis of patients with gestational diabetes mellitus complicated with threatened preterm labor with hydroxybensamine. Methods 80 patients with gestational diabetes mellitus in obstetrics and gynecology in our hospital from January 2018 to January 2019 were randomly divided into two groups. 40 patients in the control group were treated with magnesium sulfate， and 40 patients in the observation group were treated with hydroxybenzylephedrine. Results The total effective rate and the success rate of fetus prevalence in the observation group were higher than those in the control group （P<0.05）. The cumulative medication time and vaginal bleeding time in the observation group were less than the control group， and the prolonged pregnancy time was longer than the control group. The weight was higher than that of the control group （P<0.05）; the adverse reaction rate of the observation group was lower than that of the control group （P<0.05）. Conclusion Patients with gestational diabetes mellitus and threatened preterm labor with oxymethyl hydroxyephedrine can improve the total effective rate and success rate of fetus， shorten the time of medication and vaginal bleeding， prolong pregnancy， improve the weight of newborns， and have higher safety.

[Key words] Gestational diabetes; Threatened premature labor; Hydroxybenzyl hydroxyephedrine; Total effective rate; Miscarriages prevention rate

先兆早产为妊娠期多发性高危疾病类型，临床以未足月前，孕妇有呈规则性或不规则性宫缩出现，且宫颈管存在进行性缩短变化为特征。可严重威胁到母婴健康，尤其是妊娠糖尿病患者，在病发先兆早产时，病情更为复杂，进一步加大了病情控制难度。硫酸镁为常用对本病治疗的药物，属宫缩抑制剂，但长期或过量使用，可引发呼吸抑制等系列不良事件。而羟苄羟麻黄碱可有效规避上述不足，在抑制宫缩、保障临床安全同时，还可延长子宫收缩周期，具有非常重要的应用价值[1-2]。该次研究对相关病例予以选取，探讨采用苄羟麻黄碱治疗的作用，以指导临床，现报道如下。

1  资料与方法

1.1  一般资料

选择该院妇产科月收治妊娠期糖尿病患者80例。随机分组，观察组40例，年龄介于27～35岁之间，平均（29.8±1.3）岁;孕周介于33～35周之间，平均（34.6±0.3）周;对照组40例，年龄介于25～37岁之间，平均（29.5±1.4）岁;孕周介于33～36周之间，平均（34.9±0.4）周;组间自然信息均衡可比（P>0.05）。

1.2  纳排标准

纳入标准：经临床检查、血糖水平检测，与诊断标准符合;自愿签署知情同意书。排除标准：对该次所用药物存在过敏反应者;肝肾功能异常者。