张丽萍

[摘要] 目的 探讨131I治疗重度甲亢患者的临床有效率及安全性评价。 方法 选取2017年4月～2018年4月我院收治的重度甲亢患者96例作为研究对象，按照随机数字表法分为对照组（n=48）与观察组（n=48），对照组采取常规药物治疗，观察组采取常规药物联合131I治疗。比较两组患者疗效、甲亢症状好转的时间、甲状腺生化功能指标好转时间、治疗前后两组患者甲状腺功能、生存质量水平和不良反应。 结果 观察组疗效高于对照组，甲亢症状好转的时间、甲状腺生化功能指标好转时间短于对照组，甲状腺功能、生存质量水平优于对照组，差异有统计学意义（P<0.05）。观察组不良反应发生率少于对照组，差异有统计学意义（P<0.05）。 结论 常规药物联合131I治疗重度甲亢效果好，且临床安全性高，可有效加速症状和指标好转，缩短疗程以及改善患者的甲状腺功能和生存质量。

[关键词] 重度甲亢患者;临床有效率;安全性;生存质量;131I

[中图分类号] R581.1          [文献标识码] B          [文章编号] 1673-9701（2019）18-0052-03

[Abstract] Objective To investigate the clinical efficacy and safety of 131I in the treatment of patients with severe hyperthyroidism. Methods A total of 96 patients with severe hyperthyroidism admitted to our hospital from April 2017 to April 2018 were enrolled. The patients were divided into the control group（48 cases） and the observation group（48 cases） according to the random number table method. The control group was treated with conventional drug treatment， and the observation group was treated with conventional drug cpmbined with 131I. The curative effect， the time of hyperthyroidism improved， the time of improvement of thyroid biochemical function index， the thyroid function and quality of life of patients before and after treatment and adverse reactions of the two groups were compared. Results The curative effect of the observation group was higher than that of the control group. The time to improve the symptoms of hyperthyroidism and the time of improvement of thyroid biochemical function index was shorter than that of the control group. The thyroid function and quality of life in the observation group were higher than those of the control group， and the difference was statistically significant（P<0.05）. The incidence of adverse reactions in the observation group was lower than that in the control group， and the difference was statistically significant（P<0.05）. Conclusion Conventional drug combined with 131I has a good effect on severe hyperthyroidism， and it has high clinical safety. It can effectively accelerate the improvement of symptoms and indicators， shorten the course of treatment and improve the thyroid function and quality of life of patients.

[Key words] Patients with severe hyperthyroidism; Clinical effectiveness; Safety; Quality of life; 131I

甲亢是指甲狀腺释放过多的甲状腺激素，促进身体的代谢功能并刺激交感神经的疾病，称为甲状腺功能亢进。严重甲状腺功能亢进患者需要及时治疗，否则容易产生甲亢危象，这对患者的生命安全有很大影响。近年来，由于用药不规律和依从性差，严重甲状腺功能亢进的发病率仍然很高。但是，由于受传统观点的影响，大多数学者仍主张抗甲状腺药物和手术治疗严重甲状腺功能亢进症。为了减轻患者的痛苦，抗甲状腺药物常用于临床治疗，但临床治疗效果不佳[1]。本研究分析了131I治疗重度甲亢患者的临床有效率及安全性评价，现报道如下。

1 资料与方法

1.1 一般资料

选取2017年4月～2018年4月我院收治的重度甲亢患者96例作为研究对象，按照随机数字表法分为对照组与观察组，每组各48例，对照组中男31例，女17例，年龄21～78岁，平均（46.25±2.89）岁。……