向云

【摘 要】 目的：分析慢性消化病患者临床症状的特点以及其肠道微生态。方法：将慢性消化病患者按照IBS、UC、CRC分为3组，比较患者的临床症状及肠道微生态状况之间的差异。结果：IBS患者多以腹痛、腹泻、大便习惯改变为主;UC患者多以腹泻、腹痛、粘液便为主;CRC患者多以腹痛、大便习惯改变和血便为主。与健康人群相比，IBS患者的双歧杆菌和乳酸杆菌明显减少，肠杆菌和真菌有所增多;UC患者的乳酸杆菌减少，肠球菌明显增多;CRC患者的双歧杆菌明显减少，肠杆菌增多。结论：不同的慢性消化病患者的主要临床症状特点不同，其肠道菌群也有所不同。

【关键词】 肠道微生态;肠易激综合征;结直肠癌;溃疡性结肠炎

【中图分类号】R57【文献标志码】B【文章编号】1005-0019（2019）09-028-01

Abstract objective： to analyze the characteristics of clinical symptoms and intestinal microecology of patients with chronic digestive diseases. Methods： patients with chronic digestive diseases were divided into three groups according to IBS， UC and CRC， and the clinical symptoms and intestinal microecological status of the patients were compared. Results： most patients with IBS had abdominal pain， diarrhea and change of stool habit. Patients with UC mainly have diarrhea， abdominal pain and mucus stool. CRC patients were mainly affected by abdominal pain， changes in stool habits and blood defecation. Compared with healthy people， bifidobacteria and lactobacillus were significantly reduced in IBS patients， while enterobacter and fungi were increased. Lactobacillus decreased and enterococcus increased in UC patients. Bifidobacteria in CRC patients were significantly reduced and enterobacter was increased. Conclusion： different patients with chronic digestive diseases have different characteristics of main clinical symptoms and intestinal flora.

Key words：

intestinal microecology; Irritable bowel syndrome; Colorectal cancer; Ulcerative colitis

人體存在有口腔、皮肤、泌尿系以及胃肠道四个微生态系统，其中肠道微生态系统实最大的和最复杂的一个。有大量研究表明肠道菌群失调与许多慢性消化疾病的发生发展有关，比如炎症性肠病（IBD）、肠易激综合症（IBS）、结直肠癌（CRC）以及肥胖等[1-2]。本研究旨在了解和分析IBS、UC、CRC患者的临床症状与肠道微生态的变化。

1 资料与方法

1.1 一般临床资料

选取2018年1月-2018年12月在我院住院治疗的180例慢性消化病患者。180名消化病患者中有IBS、UC、CRC患者各60名，其中男性97人，女性83人，患者年龄在32到68岁之间，平均年龄为50±2.6岁。所有研究对象目前无严重并发症并且在采集粪便标准之前的1月内未使用抗生素等影响肠道菌群的药物。同时在选取50名健康志愿者作为对照组，对照组人群应无胃肠道疾病且在斤3月内无腹痛、腹泻等症状。……