赵艳玲 张少丽 李玉焕

【摘 要】 目的：探讨女性焦虑障碍心理因素和甲状腺水平的相关性。方法：选择120例2016年12月～2018年12月在本院接受治疗甲状腺功能异常的围绝经期女性患者，亚临甲减组有52例，临床甲减组68例，选取56名正常女性作为研究对照组，测定研究对象甲状腺功能、SAS及SDS水平。结果：各组研究对象的SDS、SAS评分差异性较为明显，P<0.05，具有统计学意义。甲减组患者的SAS标准分明显高于对照组，P<0.05，与亚临床甲减组、对照组相比，临床甲减组患者的SDS标准分升高较为明显，P<0.05，具有统计学意义。亚临床甲减组患者的SDS标准分明显高于对照组，P<0.05，具有统计学意义。各组研究对象的SDS与SAS评分比常模高的发生率差异性较为明显，P<0.05，具有统计学意义。FT4水平和SAS评分两者呈现明显的负相关性，r=-0.327，P=0.003。SDS水平和FT4、FT3呈现明显的负相关性，r=-0.425，P=0.00，和TSH存在明显的正相关性。结论：研究表明，甲状腺功能减退的女性存在更为明显的抑郁焦虑症状，且其严重程度和患者甲状腺激素水平相关性极为密切。

【关键词】 甲状腺;女性;焦虑障碍;心理因素

【中图分类号】R365【文献标志码】A【文章编号】1005-0019（2019）09-001-01

Abstract Objective To explore the correlation between psychological factors of female anxiety disorder and thyroid level.Methods： From December 2016 to December 2018， 120 perimenopian female patients with abnormal thyroid function who received treatment in our hospital were selected. There were 52 patients in the subclinical hypothyroidism group and 68 patients in the clinical hypothyroidism group. 56 normal women were selected as the study control group to measure the thyroid function， SAS and SDS levels of the study subjects.Result ：SDS and SAS scores of subjects in each group were significantly different， P<0.05， which was statistically significant. The SAS standard score of the hypothyroidism group was significantly higher than that of the control group （P<0.05）. Compared with the subclinical hypothyroidism group and the control group， the SDS standard score of the clinical hypothyroidism group was significantly higher （P<0.05）， which was statistically significant. SDS standard score of patients in subclinical hypothyroidism group was significantly higher than that of the control group， P<0.05， with statistical significance. The incidence of SDS and SAS scores of subjects in each group was significantly higher than the norm， P<0.05， which was statistically significant.There was a significant negative correlation between FT4 level and SAS score， r=-0.327，P=0.003. There was a significant negative correlation between SDS level and FT4 and FT3， r=-0.425，P=0.00， and a significant positive correlation between SDS level and TSH.Conclusion Studies have shown that women with hypothyroidism have more significant depressive and anxiety symptoms， and the severity is closely related to thyroid hormone levels.

Key words：

Thyroid; Women; Anxiety disorders; Psychological factors

隨着近些年我国卫生事业的不断发展，使得国内医学模式也随之不断完善，越来越多的民众开始注重身心和谐的新型健康模式，同时也将其作为大众追求高质量生活的标准之一[1]。临床在内分泌系统病症的研究中，作为一种常见病症，甲状腺异常患者往往会表现出多种情绪障碍，由此引发大量专家学者的重视。研究发现，相比于正常群体，甲状腺功能异常病患更易出现抑郁、焦虑等心理障碍[2]。对于女性来说，绝经期是其卵巢功能衰退的过渡阶段，女性在该时期很容易出现抑郁、焦虑、紧张等症状。此外，绝经期女性存在较高的甲状腺功能异常发生率，而甲状腺功能异常是否会对绝经期女性情绪状态产生影响，是目前医学界需要研究的重点课题[3]。该研究主要分析与探讨女性焦虑障碍心理因素和甲状腺水平的相关性，以期能够在诊断与治疗甲状腺功能异常并发焦虑障碍病症方面提供研究依据。

1 资料和方法

1.1 基本资料

选择120例2016年12月～2018年12月……