姚翠英 陈芳

[摘要]目的：评价眼周年轻化术后A型肉毒毒素联合透明质酸注射对眼周皱纹的改善作用。方法：按照随机数字法将2017年1月-2018年1月于笔者医院拟行眼周年轻化手术的70例患者分为对照组及观察组，每组35例。对照组行常规整形手术治疗，观察组在常规整形术后眼周注射A型肉毒毒素联合透明质酸。比较两组皱纹改善总有效率、康复时间及不良反应情况。结果：观察组总有效率为94.29%高于对照组的65.71%，差异具有统计学意义（χ2=12.447，P=0.000）。观察组与对照组的康复时间分别为（13.75±2.63）d、（16.97±3.14）d，组间比较差异具有统计学意义（t=2.593，P=0.024）。观察组不良反应发生率为8.57%低于对照组的22.86%，差异具有统计学意义（χ2=8.257，P=0.011）。结论：眼周年轻化术后A型肉毒毒素联合透明质酸注射对眼周皱纹具有显著改善作用，且能明显降低不良反应，可有效促进患者康复。

[关键词]眼周年轻化;眼周皱纹;A型肉毒毒素;透明质酸;改善作用;注射美容

[中图分类号]R622    [文献标志码]A    [文章编号]1008-6455（2019）02-0100-03

Abstract： Objective  To evaluate the improved effects of botulinum toxin type A combined with hyaluronic acid injection on periocular wrinkle after periocular rejuvenation surgery.  Methods  70 patients were planned to carry out periocular rejuvenation surgery which was divided into control group and observation group according to random number table in our hospital from January 2017 to January 2018， 35 cases in each group. The patients were carried out conventional operation in control group and the patinets were given periocular injection of botulinum toxin type A combined with hyaluronic acid after surgery in observation group. The total effective rate of wrinkle improvement， recovery time and adverse reaction was compared between two groups. Results  The total effective rate of the observation group was 94.29% higher than that of the control group， the difference was statistically significant（65.71%， χ2=12.447， P=0.000）. Rehabilitation time of the observation group and the control group were （13.75±2.63）d and （16.97±3.14）d， respectively， there was a significant difference between the two groups（t=2.593，P=0.024）. The incidence of adverse reactions in the observation group was 8.57%， which was lower than that in the control group （22.86%， χ2=8.257， P=0.011）. Conclusion  Postoperative injection of botulinum toxin  type A combined with hyaluronic acid could significantly improve the periocular wrinkle. It could obviously decrease the adverse reaction and effectively promote the rehabilitation of patients.

Key words： periocular rejuvenation; periocular wrinkle; botulinum toxin  type A; hyaluronic acid; improved effect; injection cosmetic

近几年，我国的美容技术得到了迅速发展，特别是微整形技术在临床上被广泛应用。随着年纪的增长，人面部皮肤会逐渐老化，发生皮肤松弛，出现皱纹等，而皱纹会随着岁月的增長不断加深及增多[1]。在30岁以后，人的面部开始出现明显的衰老，由于眼周的皮肤比较薄且相当敏感，眼睑的表皮角质有而比较薄，肌肤中的微血管非常细小，故眼周更加容易出现皱纹而显现出衰老[2]。因此，对面部衰老进行改善首先要进行眼周年轻化，改善眼周皱纹是非常重要的。……