张鹏飞 王明亚

[摘要] 目的 探討糖尿病周围神经病变患者行硫辛酸治疗的临床价值。方法 方便选取该院于2017年6月—2019年6月期间收治的糖尿病周围神经病变患者40例纳入研究中，以随机数字表法的形式将其平均分为实验组和对照组，各为20例。实验组行硫辛酸治疗，对照组行天麻素注射液治疗，对比两组治疗后的神经症状、冷热和振动感觉、传导速度、满意度和安全度。结果 ①两组治疗前后各项指标对比差异有统计学意义，治疗后实验组疼痛（0.92±0.53）分、烧灼（1.10±0.53）分、感觉障碍（1.02±1.45）分、麻木（0.88±0.71）分优于对照组（1.32±0.40）分、（1.88±0.51）分、（2.60±0.52）分、（1.58±0.48）分，组间对比差异有统计学意义（t=2.694、4.742、4.587、3.653，P<0.05）;②两组治疗前冷热和振动感觉分析，差异无统计学意义（P>0.05），治疗后实验组冷热觉（25.58±7.02）℃、烧热感觉（29.82±3.84）℃、振动觉（25.11±11.91）V优于对照组（31.11±8.06）℃、（33.71±2.78）℃、（34.22±16.19）V，差异有统计学意义（t=2.314、3.670、2.027，P<0.05）;实验组和对照组治疗后对比，实验组神经传导速度改善明显（P<0.05）;实验组总满意度85%高于对照组55%，两组对比，差异有统计学意义（χ2=4.286，P=0.038）。实验组中，有2例在应用第3日后存在轻微胸闷感，和滴速较快有关，滴速调整后在120 min内症状改善。对照组患者无明显不良反应。结论 硫辛酸可以有效缓解2型糖尿病患者的周围神经病变，同时不会出现不良反应。

[关键词] 硫辛酸;2型糖尿病;周围神经病变;不良反应;指标分析

[中图分类号] R587.2          [文献标识码] A          [文章编号] 1674-0742（2019）11（a）-0082-03

Therapeutic Effect of Lipoic Acid on Diabetic Peripheral Neuropathy

ZHANG Peng-fei， WANG Ming-ya

Changzhou People's Hospital， Xinbei District， Changzhou， Jiangsu Province， 213131 China

[Abstract] Objective To investigate the clinical value of lipoic acid therapy in patients with diabetic peripheral neuropathy. Methods Forty patients with diabetic peripheral neuropathy admitted to the hospital from June 2017 to June 2019 were inConveniently selected into the study. They were divided into experimental group and control group by random number table method. For 20 cases in each group. The experimental group was treated with lipoic acid， and the control group was treated with gastrodin injection. The neurological symptoms， hot and cold sensation， conduction velocity， satisfaction and safety were compared between the two groups. Results 1. The comparison of the indexes before and after treatment was statistically significant. After treatment， the experimental group had pain （0.92±0.53）points， cauterization （1.10±0.53） points， sensory disturbance （1.02±1.45） points， and numbness （0.88±0.71） points， better than the control group （1.32±0.40） points， （1.88±0.51） points， （2.60±0.52） points， and （1.58±0.48） points， and the comparison between the groups was statistically significant （t=2.694， 4.742， 4.587， 3.653， P<0.05）; 2.There was no statistically significant difference between the two groups before treatment （P>0.05）. After treatment， the experimental group had cold and heat sensation （25.58±7.02）℃ and burning sensation （29.82±3.84）℃. The vibrational sensation （25.11±11.91）V was superior to the control group （31.11±8.06）℃， （33.71±2.78）℃， （34.22±16.19）V， and the difference between groups was statistically significant（t=2.314， 3.670， 2.027， P<0.05）; the experimental group and the control group were treated. After contrast， the nerve conduction velocity of the experimental group improved significantly （P<0.05）; the total satisfaction of the experimental group was 85% higher than that of the control group（55%）， and the difference between the two groups was statistically significant（χ2=4.286， P=0.038）. In the experimental group， 2 patients had a slight chest tightness after the third day of application， which was related to the faster drip rate， and the symptoms improved within 120 min after the drip rate adjustment. There were no significant adverse reactions in the control group. Conclusion Lipoic acid can effectively alleviate peripheral neuropathy in patients with type 2 diabetes without adverse reactions.

[Key words] Lipoic acid; Type 2 diabetes; Peripheral neuropathy; Adverse reactions; Index analysis

作为糖尿病常见的慢性并发症，糖尿病神经病变可涉及到多种神经，尤其是外周神经病变最为多见，严重影响患者生命安全，也是造成糖尿病患者致残率提升的关键因素[1]。当前临床认为糖尿病导致的氧化应激伤害是慢性并发症出现的主要原因，针对于此，文章通过对该院于2017年6月—2019年6月期间收治的糖尿病周围神经病变患者40例进行分析，评定硫辛酸治疗的效果，现报道如下。

1  资料与方法

1.1  一般资料

方便选取该院收治的糖尿病周围神经病变患者40例，采用随机数字表法的形式将其平均分为实验组（n=20）和对照组（n=20）。实验组中，男性9例、女性11例，平均年龄（57.7±2.2）岁;对照组中，男性12例、女性8例，平均年龄（57.6±2.0）岁，两组基线资料对比，差异无统计学意义（P>0.05），同时该次研究患者和家属知情，征得伦理委员会批准，并签署知情同意书。2……