王小红 高斌

[摘要] 目的 通過对溃疡性结肠炎脾虚湿蕴型患者分别进行健脾合剂和美沙拉嗪治疗，观察其临床效果，探究不同治疗方案的临床应用特征。方法 从2016年1月—2018年12月来该院诊治的脾虚湿蕴型溃疡性结肠炎患者中随机抽取172例，采用随机数字法随机分为对照组86例：采用美沙拉嗪治疗，治疗组86例：采用美沙拉嗪+健脾合剂治疗，观察两组临床效果。结果 治疗组治疗后症状积分腹痛为（2.97±0.73）分高于对照组（t=8.563，P<0.05），里急后重为（2.79±1.52）分高于对照组（t=8.135，P<0.05），腹泻为（2.98±0.62）分高于对照组（t=8.095，P<0.05），脓血便为（2.70±0.63）分高于对照组（t=8.642，P<0.05）;治疗组疗程总有效率为95.34%高于对照组（87.21%）（χ2=8.945，P<0.05）。 结论 健脾合剂联合美沙拉嗪可有提高溃疡性结肠炎脾虚湿蕴型患者的治疗效果，临床症状得到快速缓解，是一项值得临床推广应用的治疗方案。

[关键词] 健脾合剂;美沙拉嗪;溃疡性结肠炎;脾虚湿蕴

[中图分类号] R259          [文献标识码] A          [文章编号] 1674-0742（2019）11（a）-0163-03

Discussion on Clinical Characteristics of Jianpi Mixture Combined With Mesalazine in The Treatment of 86 Cases of Ulcerative Colitis

WANG Xiao-hong1， GAO Bin2

1.Department of Ultrasound， Taixing Hospital of Traditional Chinese Medicine， Taixing， Jiangsu Province， 225400 China;2. Department of Spleen and Gastroenterology， Taixing Hospital of Traditional Chinese Medicine， Taixing， Jiangsu Province， 225400 China

[Abstract] Objective To observe the clinical effects of Jianpi Mixture and Mesalazine in patients with ulcerative colitis and spleen deficiency and dampness， and to explore the clinical application characteristics of different treatment options. Methods A total of 172 patients with spleen-deficiency and ulcerative colitis from January 2016 to December 2018 in the hospital were randomly selected and randomly divided into the control group by 86 patients： treated with mesalazine. 86 patients in the treatment group： treated with mesalazine + Jianpi mixture， the clinical effects of the two groups were observed. Results The score of symptom after treatment，abdominal pain in the treatment group was （2.97±0.73）points， which was higher than that in the control group （t=8.563， P<0.05）. The weight after urgency was （2.79±1.52）points， which was higher than that of the control group （t=8.135， P<0.05）， and the diarrhea was （2.98±0.62）points， higher than the control group （t=8.095， P<0.05）， the pus and blood was （2.70±0.63） points higher than the control group （t=8.642， P<0.05）; the total effective rate of the treatment group was 95.34% higher than the control group （87.21%） （χ2=8.945， P<0.05）. Conclusion Jianpi mixture combined with mesalazine can improve the therapeutic effect of patients with ulcerative colitis and spleen deficiency and dampness， and the clinical symptoms can be quickly relieved. It is a therapeutic plan worthy of clinical application.

[Key words] Jianpi mixture; Mesalazine; Ulcerative colitis; Spleen deficiency

溃疡性结肠炎又被称为慢性非特异性溃疡性结肠炎，属于结肠和直肠炎症疾病，病因不明[1]。病变主要局限在黏膜下层和肠黏膜，溃疡是该病的主要表现，常累及远端结肠、直肠。临床症状为黏液性脓血便、腹痛、腹泻。该病复发性强，容易迁延，与结肠癌相关联[2]。青壮年为该病的高发人群[3]。现代医学从控制炎性反应、调节免疫等方面进行治疗，效果不佳[4]。从来该院诊治的2016年1月—2018年12月的脾虚湿蕴型溃疡性结肠炎患者中随机抽取172例，采用随机数字法随机分为对照组和治疗组，分别采用美沙拉嗪和美沙拉嗪联合该院研发制剂健脾合剂治疗，现报道如下。

1  资料与方法

1.1  一般资料

从来该院诊治的溃疡性结肠炎患者中症状属脾虚湿蕴型患者中随机抽取172例，男性62例、女性110例，年龄范围18～72岁，平均年龄为（48.64±6.24）岁。采用随机数字法随机分为对照组86例：31例男性、55例女性，平均年龄为（49.64±7.42）岁;治疗组86例：31例男性、55例女性，平均年龄为（48.83±6.54）岁。……